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The circulating renin-angiotensin system and mortality among patients hospitalized for COVID-19: a mechanistic substudy of the ACTIV-4 Host Tissue trials.

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Title: The circulating renin-angiotensin system and mortality among patients hospitalized for COVID-19: a mechanistic substudy of the ACTIV-4 Host Tissue trials.
Authors: Schaich CL; Department of Surgery, Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States., Chappell MC; Department of Surgery, Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States., Shotwell MS; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Joly MM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Gibbs KW; Department of Internal Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States., Barksdale A; Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States., Douglas IS; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Denver Health Medical Center, Anschutz School of Medicine, University of Colorado, Denver, Colorado, United States., Chen P; Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States., Levitt JE; Department of Medicine, Stanford University, Stanford, California, United States., Puskarich MA; Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota, United States., Rice TW; Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Institute for Clinical Trials Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Harkins MS; Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States., Hudock KM; Department of Medicine, University of Cincinnati, Cincinnati, Ohio, United States., Lanspa MJ; Department of Pulmonary/Critical Care Medicine, Intermountain Medical Center, Murray, Utah, United States., Ginde AA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States., Self WH; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Collins SP; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Geriatric Research and Education Center, Veterans Affairs Tennessee Valley Health System, Nashville, Tennessee, United States., Files DC; Department of Internal Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Corporate Authors: ACTIV-4 Host Tissue Investigators
Source: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2025 Mar 01; Vol. 328 (3), pp. L405-L412. Date of Electronic Publication: 2025 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The circulating renin-angiotensin system and mortality among patients hospitalized for COVID-19: a mechanistic substudy of the ACTIV-4 Host Tissue trials.
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  Data: <searchLink fieldCode="AU" term="%22Schaich+CL%22">Schaich CL</searchLink>; Department of Surgery, Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.<br /><searchLink fieldCode="AU" term="%22Chappell+MC%22">Chappell MC</searchLink>; Department of Surgery, Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.<br /><searchLink fieldCode="AU" term="%22Shotwell+MS%22">Shotwell MS</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Joly+MM%22">Joly MM</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Gibbs+KW%22">Gibbs KW</searchLink>; Department of Internal Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.<br /><searchLink fieldCode="AU" term="%22Barksdale+A%22">Barksdale A</searchLink>; Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States.<br /><searchLink fieldCode="AU" term="%22Douglas+IS%22">Douglas IS</searchLink>; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Denver Health Medical Center, Anschutz School of Medicine, University of Colorado, Denver, Colorado, United States.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States.<br /><searchLink fieldCode="AU" term="%22Levitt+JE%22">Levitt JE</searchLink>; Department of Medicine, Stanford University, Stanford, California, United States.<br /><searchLink fieldCode="AU" term="%22Puskarich+MA%22">Puskarich MA</searchLink>; Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, Minnesota, United States.<br /><searchLink fieldCode="AU" term="%22Rice+TW%22">Rice TW</searchLink>; Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Institute for Clinical Trials Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Harkins+MS%22">Harkins MS</searchLink>; Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States.<br /><searchLink fieldCode="AU" term="%22Hudock+KM%22">Hudock KM</searchLink>; Department of Medicine, University of Cincinnati, Cincinnati, Ohio, United States.<br /><searchLink fieldCode="AU" term="%22Lanspa+MJ%22">Lanspa MJ</searchLink>; Department of Pulmonary/Critical Care Medicine, Intermountain Medical Center, Murray, Utah, United States.<br /><searchLink fieldCode="AU" term="%22Ginde+AA%22">Ginde AA</searchLink>; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.<br /><searchLink fieldCode="AU" term="%22Self+WH%22">Self WH</searchLink>; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Collins+SP%22">Collins SP</searchLink>; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Geriatric Research and Education Center, Veterans Affairs Tennessee Valley Health System, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Files+DC%22">Files DC</searchLink>; Department of Internal Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
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