Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR.

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Title: Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR.
Authors: Lanot A; Normandie Univ, UNICAEN, CHU de Caen Normandie, Néphrologie, Caen, France. antoine.lanot@gadz.org.; Normandie Université, Unicaen, UFR de Médecine, 2 Rue Des Rochambelles, Caen, France. antoine.lanot@gadz.org.; ANTICIPE' U1086 INSERM-UCN, Centre François Baclesse, Caen, France. antoine.lanot@gadz.org., Akesson A; Skane University Hospital, Clinical Studies Sweden Forum South, Remissgatan 4, Lund, 22185, Sweden.; Lund University, Malmö, Sweden., Nakano FK; Department of Public Health and Primary Care, KU Leuven, Campus Kulak, Kortrijk, Belgium.; Itec, Imec Research Group, KU Leuven, Kortrijk, Belgium., Vens C; Department of Public Health and Primary Care, KU Leuven, Campus Kulak, Kortrijk, Belgium.; Itec, Imec Research Group, KU Leuven, Kortrijk, Belgium., Björk J; Lund University, Box 117, 221 00, Lund, Sweden., Nyman U; Östra Vallgatan 41, 223 61, Lund, Sweden., Grubb A; Department of Clinical Chemistry and Pharmacology, Laboratory Lund University, Lund, 22185, Sweden., Sundin PO; Karla Healthcare Centre, Faculty of Medicine and Health, Örebro University, Örebro, 701 85, Sweden., Eriksen BO; University Hospital of North Norway (UNN), 9038, Breivika, Troms, Norway., Melsom T; University Hospital of North Norway (UNN), 9038, Breivika, Troms, Norway., Rule AD; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Berg U; Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University. Hospital Huddinge, 14186, Stockholm, Sweden., Littmann K; Department of Medicine Huddinge, Karolinska Institutet, C2:91 Karolinska University Hospital, Huddinge, SE-141 52, Sweden., Åsling-Monemi K; Barnnjursektionen K 88, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital, Stockholm, 141 86, Sweden., Hansson M; Department of Clinical Chemistry, C1:74 Huddinge, Karolinska University Hospital, Stockholm, SE-141 86, Sweden., Larsson A; Clinical Chemistry and Pharmacology, Entrance 61, 2Nd Floor, Akademiska Hospital, 751 85, Uppsala, Sweden., Courbebaisse M; Service de Physiologie-Explorations, Fonctionnelles Renales Hopital Europeen Georges Pompidou, 20 Rue Leblanc, Paris, 75015, France., Dubourg L; Exploration Fonctionnelle Renale Pavillon P, Hopital Edouard Herriot, 5 Place d'Arsonval, 69437, Lyon, Cedex 03, France., Couzi L; CHU de Bordeaux, Nephrologie-Transplantation-Dialyse, Hopital Pellegrin, Universite de Bordeaux, Place Amelie Raba Leon, Bordeaux, 33076, France., Gaillard F; Renal Transplantation Department, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Bichat, 46 Rue Henri Huchard, Paris, 75018, France., Garrouste C; Department of Nephrology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Jacquemont L; Service de Nephrologie Et Immunologie Clinique, CHU de Nantes, 30 Boulevard Jean Monnet, 44093, Nantes, Cedex 1, France., Kamar N; Department of Nephrology and Organ Transplantation, CHU Rangueil, 1 Avenue J.Poulhes, TSA 50032, 31059, Toulouse, Cedex 9, France., Legendre C; Transplantation Renale, Hopital Necker, 145 Rue de Sevres, Paris, 75015, France., Rostaing L; Service de Nephrologie, Hemodialyse, Aphereses Et Transplantation Renale, Hopital Michallon, Centre Hospitalier Universitaire Grenoble-Alpes, Boulevard de La Chantourne, La Tronche, 38700, France., Ebert N; Institute of Public Health, Charité. Universitätsmedizin Berlin, Luisenstrasse 57, Berlin, 10117, Germany., Schaeffner E; Institute of Public Health, Charité. Universitätsmedizin Berlin, Luisenstrasse 57, Berlin, 10117, Germany., Bökenkamp A; Amsterdam UMC, Vrije Universiteit, De Boelelaan 1112, Amsterdam, 1081 HV, the Netherlands., Mariat C; Service de Nephrologie, Dialyse Et Transplantation Renale, Hopital Nord, CHU de Saint-Etienne, 25 Boulevard Pasteur, 42055, Saint-Etienne, Cedex 2, France., Pottel H; Department of Public Health and Primary Care, KU Leuven, Campus Kulak, Kortrijk, Belgium., Delanaye P; Department of Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France.
Source: BMC nephrology [BMC Nephrol] 2025 Jan 30; Vol. 26 (1), pp. 47. Date of Electronic Publication: 2025 Jan 30.
Publication Type: Journal Article; Observational Study; Validation Study; Comparative Study
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR.
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  Data: <searchLink fieldCode="AU" term="%22Lanot+A%22">Lanot A</searchLink>; Normandie Univ, UNICAEN, CHU de Caen Normandie, Néphrologie, Caen, France. antoine.lanot@gadz.org.; Normandie Université, Unicaen, UFR de Médecine, 2 Rue Des Rochambelles, Caen, France. antoine.lanot@gadz.org.; ANTICIPE' U1086 INSERM-UCN, Centre François Baclesse, Caen, France. antoine.lanot@gadz.org.<br /><searchLink fieldCode="AU" term="%22Akesson+A%22">Akesson A</searchLink>; Skane University Hospital, Clinical Studies Sweden Forum South, Remissgatan 4, Lund, 22185, Sweden.; Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Nakano+FK%22">Nakano FK</searchLink>; Department of Public Health and Primary Care, KU Leuven, Campus Kulak, Kortrijk, Belgium.; Itec, Imec Research Group, KU Leuven, Kortrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Vens+C%22">Vens C</searchLink>; Department of Public Health and Primary Care, KU Leuven, Campus Kulak, Kortrijk, Belgium.; Itec, Imec Research Group, KU Leuven, Kortrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Björk+J%22">Björk J</searchLink>; Lund University, Box 117, 221 00, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Nyman+U%22">Nyman U</searchLink>; Östra Vallgatan 41, 223 61, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Grubb+A%22">Grubb A</searchLink>; Department of Clinical Chemistry and Pharmacology, Laboratory Lund University, Lund, 22185, Sweden.<br /><searchLink fieldCode="AU" term="%22Sundin+PO%22">Sundin PO</searchLink>; Karla Healthcare Centre, Faculty of Medicine and Health, Örebro University, Örebro, 701 85, Sweden.<br /><searchLink fieldCode="AU" term="%22Eriksen+BO%22">Eriksen BO</searchLink>; University Hospital of North Norway (UNN), 9038, Breivika, Troms, Norway.<br /><searchLink fieldCode="AU" term="%22Melsom+T%22">Melsom T</searchLink>; University Hospital of North Norway (UNN), 9038, Breivika, Troms, Norway.<br /><searchLink fieldCode="AU" term="%22Rule+AD%22">Rule AD</searchLink>; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Berg+U%22">Berg U</searchLink>; Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University. Hospital Huddinge, 14186, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Littmann+K%22">Littmann K</searchLink>; Department of Medicine Huddinge, Karolinska Institutet, C2:91 Karolinska University Hospital, Huddinge, SE-141 52, Sweden.<br /><searchLink fieldCode="AU" term="%22Åsling-Monemi+K%22">Åsling-Monemi K</searchLink>; Barnnjursektionen K 88, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital, Stockholm, 141 86, Sweden.<br /><searchLink fieldCode="AU" term="%22Hansson+M%22">Hansson M</searchLink>; Department of Clinical Chemistry, C1:74 Huddinge, Karolinska University Hospital, Stockholm, SE-141 86, Sweden.<br /><searchLink fieldCode="AU" term="%22Larsson+A%22">Larsson A</searchLink>; Clinical Chemistry and Pharmacology, Entrance 61, 2Nd Floor, Akademiska Hospital, 751 85, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Courbebaisse+M%22">Courbebaisse M</searchLink>; Service de Physiologie-Explorations, Fonctionnelles Renales Hopital Europeen Georges Pompidou, 20 Rue Leblanc, Paris, 75015, France.<br /><searchLink fieldCode="AU" term="%22Dubourg+L%22">Dubourg L</searchLink>; Exploration Fonctionnelle Renale Pavillon P, Hopital Edouard Herriot, 5 Place d'Arsonval, 69437, Lyon, Cedex 03, France.<br /><searchLink fieldCode="AU" term="%22Couzi+L%22">Couzi L</searchLink>; CHU de Bordeaux, Nephrologie-Transplantation-Dialyse, Hopital Pellegrin, Universite de Bordeaux, Place Amelie Raba Leon, Bordeaux, 33076, France.<br /><searchLink fieldCode="AU" term="%22Gaillard+F%22">Gaillard F</searchLink>; Renal Transplantation Department, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Bichat, 46 Rue Henri Huchard, Paris, 75018, France.<br /><searchLink fieldCode="AU" term="%22Garrouste+C%22">Garrouste C</searchLink>; Department of Nephrology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Jacquemont+L%22">Jacquemont L</searchLink>; Service de Nephrologie Et Immunologie Clinique, CHU de Nantes, 30 Boulevard Jean Monnet, 44093, Nantes, Cedex 1, France.<br /><searchLink fieldCode="AU" term="%22Kamar+N%22">Kamar N</searchLink>; Department of Nephrology and Organ Transplantation, CHU Rangueil, 1 Avenue J.Poulhes, TSA 50032, 31059, Toulouse, Cedex 9, France.<br /><searchLink fieldCode="AU" term="%22Legendre+C%22">Legendre C</searchLink>; Transplantation Renale, Hopital Necker, 145 Rue de Sevres, Paris, 75015, France.<br /><searchLink fieldCode="AU" term="%22Rostaing+L%22">Rostaing L</searchLink>; Service de Nephrologie, Hemodialyse, Aphereses Et Transplantation Renale, Hopital Michallon, Centre Hospitalier Universitaire Grenoble-Alpes, Boulevard de La Chantourne, La Tronche, 38700, France.<br /><searchLink fieldCode="AU" term="%22Ebert+N%22">Ebert N</searchLink>; Institute of Public Health, Charité. Universitätsmedizin Berlin, Luisenstrasse 57, Berlin, 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Schaeffner+E%22">Schaeffner E</searchLink>; Institute of Public Health, Charité. 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