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Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects.

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Title: Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects.
Authors: Downie CG; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA. Electronic address: cdownie@live.unc.edu., Shrestha P; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA; Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Okello S; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA., Yaser M; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA., Lee HH; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA., Wang Y; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA., Krishnan M; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA; Carolina Population Center, UNC Chapel Hill, Chapel Hill, NC, USA., Chen HH; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Justice AE; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA., Chittoor G; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA., Josyula NS; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA., Gahagan S; Department of Pediatrics, University of San Diego, La Jolla, CA 92093, USA., Blanco E; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile., Burrows R; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile., Correa-Burrows P; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile., Albala C; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile., Santos JL; Department of Nutrition, Diabetes and Metabolism. School of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile., Angel B; Public Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile., Lozoff B; Department of Pediatrics, Medical School, and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Horta B; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Brina KR; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Gallo LC; Department of Psychology, San Diego State University, Chula Vista, CA 91910, USA., Perreira KM; Department of Social Medicine, University of North Carolina, Chapel Hill, NC 27599, USA., Thyagarajan B; Department of Epidemiology, University of Minnesota Medical Center, Minneapolis, MN 55454, USA., Daviglus M; Department of Preventive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Van Horn L; Department of Preventive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Gonzalez F; Collaborative Studies Coordinating Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA., Bradfield JP; Quantinuum Research LLC, Wayne, PA, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Below JE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Felix J; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Graff M; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA., Divaris K; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA; Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., North KE; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA. Electronic address: kari_north@unc.edu.
Source: HGG advances [HGG Adv] 2025 Apr 10; Vol. 6 (2), pp. 100411. Date of Electronic Publication: 2025 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects.
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  Data: <searchLink fieldCode="AU" term="%22Downie+CG%22">Downie CG</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA. Electronic address: cdownie@live.unc.edu.<br /><searchLink fieldCode="AU" term="%22Shrestha+P%22">Shrestha P</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA; Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Okello+S%22">Okello S</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Yaser+M%22">Yaser M</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Lee+HH%22">Lee HH</searchLink>; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Krishnan+M%22">Krishnan M</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA; Carolina Population Center, UNC Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Justice+AE%22">Justice AE</searchLink>; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA.<br /><searchLink fieldCode="AU" term="%22Chittoor+G%22">Chittoor G</searchLink>; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA.<br /><searchLink fieldCode="AU" term="%22Josyula+NS%22">Josyula NS</searchLink>; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA.<br /><searchLink fieldCode="AU" term="%22Gahagan+S%22">Gahagan S</searchLink>; Department of Pediatrics, University of San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Blanco+E%22">Blanco E</searchLink>; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Burrows+R%22">Burrows R</searchLink>; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Correa-Burrows+P%22">Correa-Burrows P</searchLink>; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Albala+C%22">Albala C</searchLink>; Centro de Investigación en Sociedad y Salud y Núcleo Milenio de Sociomedicina, Universidad Mayor, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Santos+JL%22">Santos JL</searchLink>; Department of Nutrition, Diabetes and Metabolism. 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Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Angel+B%22">Angel B</searchLink>; Public Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Lozoff+B%22">Lozoff B</searchLink>; Department of Pediatrics, Medical School, and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hartwig+FP%22">Hartwig FP</searchLink>; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Horta+B%22">Horta B</searchLink>; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Brina+KR%22">Brina KR</searchLink>; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Isasi+CR%22">Isasi CR</searchLink>; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Qi+Q%22">Qi Q</searchLink>; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Gallo+LC%22">Gallo LC</searchLink>; Department of Psychology, San Diego State University, Chula Vista, CA 91910, USA.<br /><searchLink fieldCode="AU" term="%22Perreira+KM%22">Perreira KM</searchLink>; Department of Social Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Thyagarajan+B%22">Thyagarajan B</searchLink>; Department of Epidemiology, University of Minnesota Medical Center, Minneapolis, MN 55454, USA.<br /><searchLink fieldCode="AU" term="%22Daviglus+M%22">Daviglus M</searchLink>; Department of Preventive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Van+Horn+L%22">Van Horn L</searchLink>; Department of Preventive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+F%22">Gonzalez F</searchLink>; Collaborative Studies Coordinating Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Bradfield+JP%22">Bradfield JP</searchLink>; Quantinuum Research LLC, Wayne, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hakonarson+H%22">Hakonarson H</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Grant+SFA%22">Grant SFA</searchLink>; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Below+JE%22">Below JE</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Felix+J%22">Felix J</searchLink>; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Graff+M%22">Graff M</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Divaris+K%22">Divaris K</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA; Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22North+KE%22">North KE</searchLink>; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514, USA. Electronic address: kari_north@unc.edu.
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