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Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies.

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Title: Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies.
Authors: Aziz MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519 Egypt., Salem IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assiut City, Assiut 71515, Egypt., Al-Awadh MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alharbi AS; Department of Chemistry, College of Science and Humanities-Dawadmi, Shaqra University, Saudi Arabia., Elsayed Abouzed DE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt., Allam RM; Pharmacology Department, Medical Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Ahmed OAA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, 21589 Jeddah, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519 Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Egypt. Electronic address: gamal.aborahma@mu.edu.eg., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: mamdouh.fawzi@pharm.sohag.edu.eg.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Mar; Vol. 156, pp. 108181. Date of Electronic Publication: 2025 Jan 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2120
DOI:10.1016/j.bioorg.2025.108181