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Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition.

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Title: Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition.
Authors: Madorsky Rowdo FP; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Martini R; Department of Surgery, Weill Cornell Medicine, New York, New York.; Institute of Translational Genomic Medicine, Morehouse School of Medicine, Atlanta, Georgia., Ackermann SE; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Tang CP; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York., Tranquille M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Irizarry A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Us I; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Alawa O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Moyer JE; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Sigouros M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Nguyen J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Al Assaad M; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Cheng E; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Ginter PS; Department of Pathology, NYU Langone Hospital-Long Island, Mineola, New York., Manohar J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Stonaker B; Department of Surgery, Weill Cornell Medicine, New York, New York., Boateng R; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Oppong JK; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adjei EK; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Awuah B; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Kyei I; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Aitpillah FS; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adinku MO; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Ankomah K; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Osei-Bonsu EB; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Gyan KK; Department of Surgery, Weill Cornell Medicine, New York, New York., Hoda S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Newman L; Department of Surgery, Weill Cornell Medicine, New York, New York., Mosquera JM; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Sboner A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York., Dow LE; Meyer Cancer Center, Weill Cornell Medicine, New York, New York.; Department of Medicine, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York., Davis MB; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Surgery, Weill Cornell Medicine, New York, New York.; Institute of Translational Genomic Medicine, Morehouse School of Medicine, Atlanta, Georgia., Martin ML; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
Source: Cancer research [Cancer Res] 2025 Feb 01; Vol. 85 (3), pp. 551-566.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition.
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Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Us+I%22">Us I</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Alawa+O%22">Alawa O</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Moyer+JE%22">Moyer JE</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Sigouros+M%22">Sigouros M</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Al+Assaad+M%22">Al Assaad M</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; 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Meyer Cancer Center, Weill Cornell Medicine, New York, New York.; Department of Medicine, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York.<br /><searchLink fieldCode="AU" term="%22Davis+MB%22">Davis MB</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Surgery, Weill Cornell Medicine, New York, New York.; Institute of Translational Genomic Medicine, Morehouse School of Medicine, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Martin+ML%22">Martin ML</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
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