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Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.

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Title: Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.
Authors: Zhang Z; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China., Geng C; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China., Song M; Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, Zhejiang 311121, China., Liang H; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Zhou K; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China., Liu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Wu J; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China., Huang X; Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, Zhejiang 311121, China., Zhou J; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China., Fan J; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China., Peng DH; Dunwill Med-Tech Co., Ltd, Shanghai 201210, China. Electronic address: utsapeng@gmail.com., Zhang L; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: zhangly@shanghaitech.edu.cn., Cang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: cangyong@shanghaitech.edu.cn., Sun Y; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China. Electronic address: yunfan_sun@msn.com.
Source: Journal of hepatology [J Hepatol] 2025 Aug; Vol. 83 (2), pp. 397-410. Date of Electronic Publication: 2025 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Geng+C%22">Geng C</searchLink>; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.<br /><searchLink fieldCode="AU" term="%22Song+M%22">Song M</searchLink>; Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Zhou+K%22">Zhou K</searchLink>; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Peng+DH%22">Peng DH</searchLink>; Dunwill Med-Tech Co., Ltd, Shanghai 201210, China. Electronic address: utsapeng@gmail.com.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: zhangly@shanghaitech.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cang+Y%22">Cang Y</searchLink>; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: cangyong@shanghaitech.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China. Electronic address: yunfan_sun@msn.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jhep.2025.01.027
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        StartPage: 397
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      – TitleFull: Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.
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              M: 08
              Text: 2025 Aug
              Type: published
              Y: 2025
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