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MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma.

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Title: MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma.
Authors: Friker LL; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. lea.friker@ukbonn.de.; Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany. lea.friker@ukbonn.de., Perwein T; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.; Styrian Children's Cancer Research, Research Unit for Cancer and Inborn Errors of the Blood and Immunity in Children, Medical University of Graz, Graz, Austria., Waha A; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Dörner E; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Klein R; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Layer JP; Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.; Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany., Sturm D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Nussbaumer G; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Kwiecien R; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany., Spier I; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Aretz S; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Hennewig U; Department of Pediatric Hematology and Oncology, University Hospital Giessen and Marburg, Giessen, Germany., Rohde M; Department of Pediatric Hematology and Oncology, University Hospital Giessen and Marburg, Giessen, Germany., Karow A; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen, Erlangen, Germany., Bluemcke I; Institute of Neuropathology, University Hospital Erlangen, Erlangen, Germany., Schmitz AK; Department of Pediatrics, Asklepios Kinderklinik Sankt Augustin, Sankt Augustin, Germany., Reinhard H; Department of Pediatrics, Asklepios Kinderklinik Sankt Augustin, Sankt Augustin, Germany., Hernáiz Driever P; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, German HIT-LOGGIC-Registry for pLGG in Children and Adolescents, Berlin, Germany., Wendt S; Department of Pediatric Oncology and Hematology, University Hospital Leipzig, Leipzig, Germany., Weiser A; Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Guerreiro Stücklin AS; Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Gerber NU; Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland., von Bueren AO; Department of Pediatrics, Gynecology and Obstetrics, Division of Pediatric Hematology and Oncology, Geneva University Hospital, Geneva, Switzerland.; Department of Pediatrics, Gynecology and Obstetrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Khurana C; Department of Pediatric Hematology and Oncology, Children's Center Bethel, University Hospital Ostwestfalen-Lippe, Bielefeld, Germany., Jorch N; Department of Pediatric Hematology and Oncology, Children's Center Bethel, University Hospital Ostwestfalen-Lippe, Bielefeld, Germany., Wiese M; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Kratz CP; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Eyrich M; University Children's Hospital, University Hospital Würzburg, Würzburg, Germany., Karremann M; Department of Pediatric and Adolescent Medicine and Mannheim Cancer Center (MCC), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Herrlinger U; Department of Neurooncology, Center for Neurology and CIO ABCD, University Hospital Bonn, Bonn, Germany., Hölzel M; Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Hoffmann M; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Pietsch T; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Gielen GH; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Feb 02; Vol. 149 (1), pp. 11. Date of Electronic Publication: 2025 Feb 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma.
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  Data: <searchLink fieldCode="AU" term="%22Friker+LL%22">Friker LL</searchLink>; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. lea.friker@ukbonn.de.; Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany. lea.friker@ukbonn.de.<br /><searchLink fieldCode="AU" term="%22Perwein+T%22">Perwein T</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.; Styrian Children's Cancer Research, Research Unit for Cancer and Inborn Errors of the Blood and Immunity in Children, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Waha+A%22">Waha A</searchLink>; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dörner+E%22">Dörner E</searchLink>; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+R%22">Klein R</searchLink>; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Layer+JP%22">Layer JP</searchLink>; Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.; Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Sturm+D%22">Sturm D</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Nussbaumer+G%22">Nussbaumer G</searchLink>; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Kwiecien+R%22">Kwiecien R</searchLink>; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Spier+I%22">Spier I</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Aretz+S%22">Aretz S</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kerl+K%22">Kerl K</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hennewig+U%22">Hennewig U</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Giessen and Marburg, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Rohde+M%22">Rohde M</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Giessen and Marburg, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Karow+A%22">Karow A</searchLink>; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Bluemcke+I%22">Bluemcke I</searchLink>; Institute of Neuropathology, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitz+AK%22">Schmitz AK</searchLink>; Department of Pediatrics, Asklepios Kinderklinik Sankt Augustin, Sankt Augustin, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhard+H%22">Reinhard H</searchLink>; Department of Pediatrics, Asklepios Kinderklinik Sankt Augustin, Sankt Augustin, Germany.<br /><searchLink fieldCode="AU" term="%22Hernáiz+Driever+P%22">Hernáiz Driever P</searchLink>; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, German HIT-LOGGIC-Registry for pLGG in Children and Adolescents, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wendt+S%22">Wendt S</searchLink>; Department of Pediatric Oncology and Hematology, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Weiser+A%22">Weiser A</searchLink>; Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guerreiro+Stücklin+AS%22">Guerreiro Stücklin AS</searchLink>; Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gerber+NU%22">Gerber NU</searchLink>; Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22von+Bueren+AO%22">von Bueren AO</searchLink>; Department of Pediatrics, Gynecology and Obstetrics, Division of Pediatric Hematology and Oncology, Geneva University Hospital, Geneva, Switzerland.; Department of Pediatrics, Gynecology and Obstetrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Khurana+C%22">Khurana C</searchLink>; Department of Pediatric Hematology and Oncology, Children's Center Bethel, University Hospital Ostwestfalen-Lippe, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Jorch+N%22">Jorch N</searchLink>; Department of Pediatric Hematology and Oncology, Children's Center Bethel, University Hospital Ostwestfalen-Lippe, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Wiese+M%22">Wiese M</searchLink>; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kratz+CP%22">Kratz CP</searchLink>; 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