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Multiomic analysis uncovers a continuous spectrum of differentiation and Wnt-MDK-driven immune evasion in hepatoblastoma.

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Title: Multiomic analysis uncovers a continuous spectrum of differentiation and Wnt-MDK-driven immune evasion in hepatoblastoma.
Authors: Münter D; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., de Faria FW; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Richter M; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Aranda-Pardos I; Institute of Immunology, University of Münster, Münster, Germany., Hotfilder M; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Walter C; Institute of Medical Informatics, University of Münster, Münster, Germany., Paga E; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Inserte C; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany; Institute of Medical Informatics, University of Münster, Münster, Germany., Albert TK; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Roy R; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Rahman S; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Riedel NC; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Müller V; Department of Pediatric Surgery, University Hospital Münster, Münster, Germany., Pascher A; Department of General, Visceral and Transplantation Surgery, University Hospital Münster, Münster, Germany., Wiebe K; Department of Cardiothoracic Surgery, University Hospital Münster, Münster, Germany., Schmid I; Department of Pediatric Oncology and Hematology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Vokuhl C; Institute of Pathology, University Hospital Bonn, Bonn, Germany., Winkler B; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jüttner E; Department of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Vieth S; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Mücke U; Pediatric Oncology and Hematology, Medical School of Hanover, Hanover, Germany., Kluiver TA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Peng WC; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Rossig C; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Schlué J; Institute for Pathology, Medical School of Hanover, Hanover, Germany., Madadi-Sanjani O; Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sandmann S; Institute of Medical Informatics, University of Münster, Münster, Germany., Hartmann W; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany., A-Gonzalez N; Institute of Immunology, University of Münster, Münster, Germany., Soehnlein O; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany. Electronic address: Kornelius.Kerl@ukmuenster.de.
Source: Journal of hepatology [J Hepatol] 2025 Aug; Vol. 83 (2), pp. 367-382. Date of Electronic Publication: 2025 Feb 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiomic analysis uncovers a continuous spectrum of differentiation and Wnt-MDK-driven immune evasion in hepatoblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Münter+D%22">Münter D</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22de+Faria+FW%22">de Faria FW</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Aranda-Pardos+I%22">Aranda-Pardos I</searchLink>; Institute of Immunology, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hotfilder+M%22">Hotfilder M</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Walter+C%22">Walter C</searchLink>; Institute of Medical Informatics, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Paga+E%22">Paga E</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Inserte+C%22">Inserte C</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany; Institute of Medical Informatics, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Albert+TK%22">Albert TK</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Roy+R%22">Roy R</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Rahman+S%22">Rahman S</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Riedel+NC%22">Riedel NC</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+V%22">Müller V</searchLink>; Department of Pediatric Surgery, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Pascher+A%22">Pascher A</searchLink>; Department of General, Visceral and Transplantation Surgery, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Wiebe+K%22">Wiebe K</searchLink>; Department of Cardiothoracic Surgery, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+I%22">Schmid I</searchLink>; Department of Pediatric Oncology and Hematology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vokuhl+C%22">Vokuhl C</searchLink>; Institute of Pathology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Winkler+B%22">Winkler B</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jüttner+E%22">Jüttner E</searchLink>; Department of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Vieth+S%22">Vieth S</searchLink>; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Mücke+U%22">Mücke U</searchLink>; Pediatric Oncology and Hematology, Medical School of Hanover, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Kluiver+TA%22">Kluiver TA</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peng+WC%22">Peng WC</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rossig+C%22">Rossig C</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schlué+J%22">Schlué J</searchLink>; Institute for Pathology, Medical School of Hanover, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Madadi-Sanjani+O%22">Madadi-Sanjani O</searchLink>; Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sandmann+S%22">Sandmann S</searchLink>; Institute of Medical Informatics, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+W%22">Hartmann W</searchLink>; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22A-Gonzalez+N%22">A-Gonzalez N</searchLink>; Institute of Immunology, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Soehnlein+O%22">Soehnlein O</searchLink>; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Kerl+K%22">Kerl K</searchLink>; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany. Electronic address: Kornelius.Kerl@ukmuenster.de.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2025 Aug; Vol. 83 (2), pp. 367-382. <i>Date of Electronic Publication: </i>2025 Feb 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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