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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer.

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Title: Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer.
Authors: Duranti C; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy., Iorio J; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy., Manganelli V; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy., Bagni G; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy., Colasurdo R; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Lottini T; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy., Martinelli M; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Capitani C; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy., Boso G; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy., D'Alessandro FN; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Sorice M; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy., Becchetti A; Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy., Misasi R; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy., Garofalo T; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy., Arcangeli A; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy. annarosa.arcangeli@unifi.it.
Source: Cell death discovery [Cell Death Discov] 2025 Feb 03; Vol. 11 (1), pp. 39. Date of Electronic Publication: 2025 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Duranti+C%22">Duranti C</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Iorio+J%22">Iorio J</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Manganelli+V%22">Manganelli V</searchLink>; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bagni+G%22">Bagni G</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Colasurdo+R%22">Colasurdo R</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Lottini+T%22">Lottini T</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Martinelli+M%22">Martinelli M</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Capitani+C%22">Capitani C</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Boso+G%22">Boso G</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+FN%22">D'Alessandro FN</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Sorice+M%22">Sorice M</searchLink>; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Becchetti+A%22">Becchetti A</searchLink>; Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Misasi+R%22">Misasi R</searchLink>; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Garofalo+T%22">Garofalo T</searchLink>; Department of Experimental Medicine, 'Sapienza' University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Arcangeli+A%22">Arcangeli A</searchLink>; Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy. annarosa.arcangeli@unifi.it.
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