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Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile.

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Title: Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile.
Authors: Burban A; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France., Tessier C; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Larroquette M; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France., Guyon J; CHU of Bordeaux, Service de Pharmacologie Médicale, Bordeaux, France.; University of Bordeaux, INSERM, BPH, U1219, Bordeaux, France., Lubiato C; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Pinglaut M; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France., Toujas M; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Galvis J; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France., Dartigues B; Bordeaux Bioinformatic Center CBiB, University of Bordeaux, Bordeaux, France., Georget E; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Luchman HA; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.; Arnie Charbonneau Cancer Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada., Weiss S; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.; Arnie Charbonneau Cancer Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada., Cappellen D; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Nicot N; LuxGen Genome Center, Luxembourg Institute of Health, Laboratoire national de santé, Dudelange, Luxembourg., Klink B; LuxGen Genome Center, Luxembourg Institute of Health, Laboratoire national de santé, Dudelange, Luxembourg.; National Center of Genetics (NCG), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, 1526, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Nikolski M; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France.; Bordeaux Bioinformatic Center CBiB, University of Bordeaux, Bordeaux, France., Brisson L; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Mathivet T; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France., Bikfalvi A; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France. andreas.bikfalvi@u-bordeaux.fr., Daubon T; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France. thomas.daubon@u-bordeaux.fr., Sharanek A; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France. ahmad.charanek@u-bordeaux.fr.
Source: EMBO molecular medicine [EMBO Mol Med] 2025 Mar; Vol. 17 (3), pp. 469-503. Date of Electronic Publication: 2025 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile.
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  Data: <searchLink fieldCode="AU" term="%22Burban+A%22">Burban A</searchLink>; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Tessier+C%22">Tessier C</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Larroquette+M%22">Larroquette M</searchLink>; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Guyon+J%22">Guyon J</searchLink>; CHU of Bordeaux, Service de Pharmacologie Médicale, Bordeaux, France.; University of Bordeaux, INSERM, BPH, U1219, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Lubiato+C%22">Lubiato C</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Pinglaut+M%22">Pinglaut M</searchLink>; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Toujas+M%22">Toujas M</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Galvis+J%22">Galvis J</searchLink>; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Dartigues+B%22">Dartigues B</searchLink>; Bordeaux Bioinformatic Center CBiB, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Georget+E%22">Georget E</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Luchman+HA%22">Luchman HA</searchLink>; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.; Arnie Charbonneau Cancer Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Weiss+S%22">Weiss S</searchLink>; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.; Arnie Charbonneau Cancer Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Cappellen+D%22">Cappellen D</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Nicot+N%22">Nicot N</searchLink>; LuxGen Genome Center, Luxembourg Institute of Health, Laboratoire national de santé, Dudelange, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Klink+B%22">Klink B</searchLink>; LuxGen Genome Center, Luxembourg Institute of Health, Laboratoire national de santé, Dudelange, Luxembourg.; National Center of Genetics (NCG), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, 1526, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Nikolski+M%22">Nikolski M</searchLink>; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France.; Bordeaux Bioinformatic Center CBiB, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Brisson+L%22">Brisson L</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Mathivet+T%22">Mathivet T</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Bikfalvi+A%22">Bikfalvi A</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France. andreas.bikfalvi@u-bordeaux.fr.<br /><searchLink fieldCode="AU" term="%22Daubon+T%22">Daubon T</searchLink>; University of Bordeaux, CNRS, IBGC, UMR5095, Bordeaux, France. thomas.daubon@u-bordeaux.fr.<br /><searchLink fieldCode="AU" term="%22Sharanek+A%22">Sharanek A</searchLink>; University of Bordeaux, INSERM, UMR1312, BRIC, BoRdeaux Institute of onCology, Bordeaux, France. ahmad.charanek@u-bordeaux.fr.
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