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EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer.

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Title: EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer.
Authors: Muller L; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France., Fauvet F; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France., Chassot C; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France., Angileri F; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.; Département de Pharmacologie, Physiologie et Toxicologie, Institut des Sciences Pharmaceutiques Et Biologiques (ISPB), Université Claude Bernard Lyon I, Lyon, France.; Unité de recherche 3738 CICLY (Centre Pour l'Innovation en Cancérologie de Lyon), Faculté de Médecine et de Maïeutique Lyon Sud - Charles Mérieux, Université Claude Bernard Lyon I, Lyon, France., Coutant A; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France., Dégletagne C; Plateforme de Génomique des Cancers, Centre de Recherche en Cancérologie de Lyon (CRCL), INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France., Tonon L; Plateforme de Bioinformatique Gilles Thomas, Synergie Lyon Cancer, Centre Léon Bérard, Lyon, France., Saintigny P; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.; CASTING - Cancer dynamics, adaptation and modeling, Inria, Inserm, Ecole Normale Supérieure de Lyon, Centre Léon Bérard, Cnrs, Université Claude Bernard Lyon 1, Lyon, France., Puisieux A; Equipe Labellisée Ligue Contre le Cancer, CNRS UMR 3666, INSERM U1143, Paris, France.; Institut Curie, PSL Research University, Paris, France., Morel AP; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France., Ouzounova M; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France.; Equipe Labellisée Ligue Contre le Cancer, CNRS UMR 3666, INSERM U1143, Paris, France., Martinez P; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France. pierre.martinez@lyon.unicancer.fr.; CASTING - Cancer dynamics, adaptation and modeling, Inria, Inserm, Ecole Normale Supérieure de Lyon, Centre Léon Bérard, Cnrs, Université Claude Bernard Lyon 1, Lyon, France. pierre.martinez@lyon.unicancer.fr.
Source: Cancer cell international [Cancer Cell Int] 2025 Feb 03; Vol. 25 (1), pp. 32. Date of Electronic Publication: 2025 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139795 Publication Model: Electronic Cited Medium: Print ISSN: 1475-2867 (Print) Linking ISSN: 14752867 NLM ISO Abbreviation: Cancer Cell Int Subsets: PubMed not MEDLINE
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  Data: EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Muller+L%22">Muller L</searchLink>; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Fauvet+F%22">Fauvet F</searchLink>; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Chassot+C%22">Chassot C</searchLink>; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Angileri+F%22">Angileri F</searchLink>; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.; Département de Pharmacologie, Physiologie et Toxicologie, Institut des Sciences Pharmaceutiques Et Biologiques (ISPB), Université Claude Bernard Lyon I, Lyon, France.; Unité de recherche 3738 CICLY (Centre Pour l'Innovation en Cancérologie de Lyon), Faculté de Médecine et de Maïeutique Lyon Sud - Charles Mérieux, Université Claude Bernard Lyon I, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Coutant+A%22">Coutant A</searchLink>; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Dégletagne+C%22">Dégletagne C</searchLink>; Plateforme de Génomique des Cancers, Centre de Recherche en Cancérologie de Lyon (CRCL), INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Tonon+L%22">Tonon L</searchLink>; Plateforme de Bioinformatique Gilles Thomas, Synergie Lyon Cancer, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Saintigny+P%22">Saintigny P</searchLink>; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.; CASTING - Cancer dynamics, adaptation and modeling, Inria, Inserm, Ecole Normale Supérieure de Lyon, Centre Léon Bérard, Cnrs, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Puisieux+A%22">Puisieux A</searchLink>; Equipe Labellisée Ligue Contre le Cancer, CNRS UMR 3666, INSERM U1143, Paris, France.; Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Morel+AP%22">Morel AP</searchLink>; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Ouzounova+M%22">Ouzounova M</searchLink>; EMT and Cancer Cell Plasticity Team, Centre Léon Bérard, Lyon, France.; Equipe Labellisée Ligue Contre le Cancer, CNRS UMR 3666, INSERM U1143, Paris, France.<br /><searchLink fieldCode="AU" term="%22Martinez+P%22">Martinez P</searchLink>; Integrated Analyses of Cancer Dynamics Team, Centre de Recherche en Cancérologie de Lyon (CRCL), Institut Convergence PlasCan, INSERM U1052, CNRSUMR 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France. pierre.martinez@lyon.unicancer.fr.; CASTING - Cancer dynamics, adaptation and modeling, Inria, Inserm, Ecole Normale Supérieure de Lyon, Centre Léon Bérard, Cnrs, Université Claude Bernard Lyon 1, Lyon, France. pierre.martinez@lyon.unicancer.fr.
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  Data: <searchLink fieldCode="JN" term="%22101139795%22">Cancer cell international</searchLink> [Cancer Cell Int] 2025 Feb 03; Vol. 25 (1), pp. 32. <i>Date of Electronic Publication: </i>2025 Feb 03.
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