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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma.

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Title: OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma.
Authors: Desai K; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Wanggou S; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Neurosurgery, and Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Luis E; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Whetstone H; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Yu C; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Vanner RJ; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Selvadurai HJ; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Lee L; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Vijay J; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Jaramillo JE; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Fan J; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Guilhamon P; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Kushida M; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Li X; Department of Neurosurgery, and Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Stein G; Curtana Pharmaceuticals, Inc, Austin, TX, 78756, USA., Kesari S; Curtana Pharmaceuticals, Inc, Austin, TX, 78756, USA.; Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, 90404, USA., Simons BD; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, CB3 0WA, UK.; The Wellcome Trust/Cancer Research UK Gurdon Institute, and the Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QN, UK., Huang X; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Dirks PB; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada. peter.dirks@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.dirks@sickkids.ca.; Division of Neurosurgery, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.dirks@sickkids.ca.
Source: Nature communications [Nat Commun] 2025 Feb 04; Vol. 16 (1), pp. 1092. Date of Electronic Publication: 2025 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Desai+K%22">Desai K</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Wanggou+S%22">Wanggou S</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Neurosurgery, and Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.<br /><searchLink fieldCode="AU" term="%22Luis+E%22">Luis E</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Whetstone+H%22">Whetstone H</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Vanner+RJ%22">Vanner RJ</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Selvadurai+HJ%22">Selvadurai HJ</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+L%22">Lee L</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Vijay+J%22">Vijay J</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Jaramillo+JE%22">Jaramillo JE</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Guilhamon+P%22">Guilhamon P</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Kushida+M%22">Kushida M</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Neurosurgery, and Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.<br /><searchLink fieldCode="AU" term="%22Stein+G%22">Stein G</searchLink>; Curtana Pharmaceuticals, Inc, Austin, TX, 78756, USA.<br /><searchLink fieldCode="AU" term="%22Kesari+S%22">Kesari S</searchLink>; Curtana Pharmaceuticals, Inc, Austin, TX, 78756, USA.; Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.<br /><searchLink fieldCode="AU" term="%22Simons+BD%22">Simons BD</searchLink>; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, CB3 0WA, UK.; The Wellcome Trust/Cancer Research UK Gurdon Institute, and the Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QN, UK.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Dirks+PB%22">Dirks PB</searchLink>; Developmental and Stem Cell Biology Program, and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada. peter.dirks@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.dirks@sickkids.ca.; Division of Neurosurgery, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.dirks@sickkids.ca.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Feb 04; Vol. 16 (1), pp. 1092. <i>Date of Electronic Publication: </i>2025 Feb 04.
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