Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study.

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Title: Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study.
Authors: Medeleanu MV; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Reyna ME; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Dai DLY; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Winsor GL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Brinkman FSL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Verma R; Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Nugent E; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada., Riaz N; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada., Simons E; Department of Pediatrics and Child Health, Section of Allergy and Immunology, University of Manitoba, Winnipeg, MB, Canada., Mandhane PJ; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.; Faculty of Medicine & Health Sciences, UCSI University, Kuala Lampur, Malaysia., Azad MB; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Turvey SE; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Moraes TJ; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada., Subbarao P; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Source: Frontiers in allergy [Front Allergy] 2025 Jan 21; Vol. 5, pp. 1463867. Date of Electronic Publication: 2025 Jan 21 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918227355906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-6101 (Electronic) Linking ISSN: 26736101 NLM ISO Abbreviation: Front Allergy Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Medeleanu+MV%22">Medeleanu MV</searchLink>; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Reyna+ME%22">Reyna ME</searchLink>; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dai+DLY%22">Dai DLY</searchLink>; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Winsor+GL%22">Winsor GL</searchLink>; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Brinkman+FSL%22">Brinkman FSL</searchLink>; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Verma+R%22">Verma R</searchLink>; Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Nugent+E%22">Nugent E</searchLink>; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Riaz+N%22">Riaz N</searchLink>; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Simons+E%22">Simons E</searchLink>; Department of Pediatrics and Child Health, Section of Allergy and Immunology, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Mandhane+PJ%22">Mandhane PJ</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.; Faculty of Medicine & Health Sciences, UCSI University, Kuala Lampur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Azad+MB%22">Azad MB</searchLink>; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Turvey+SE%22">Turvey SE</searchLink>; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Moraes+TJ%22">Moraes TJ</searchLink>; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Subbarao+P%22">Subbarao P</searchLink>; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
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