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Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive Cardiology

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Title: Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive Cardiology
Authors: Schunkert H; Department of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum der Technischen Universität München, 80636 Munich, Lazarettstrasse 36, Germany.; Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Di Angelantonio E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; Health Data Science Centre, Human Technopole, Milan, Italy., Inouye M; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia., Patel RS; Institute of Cardiovascular Sciences, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.; National Institute of Health Research Biomedical Research Centre, University College London Hospitals, London, UK., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Faculty of Medicine, University of Helsinki, Finland.; Massachusetts General Hospital & Broad Institute of MIT and Harvard, MA, USA., Widen E; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland., Sanderson SC; Public Health Genomics (PHG) Foundation, Cambridge, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Behavioural Science and Health, University College London, London, UK., Kaski JP; Centre for Paediatric Inherited and Rare Cardiovascular Disease, UCL Institute of Cardiovascular Science, London, and Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, UK., McEvoy JW; National Institute for Prevention and Cardiovascular Health, University of Galway School of Medicine, Galway, Ireland., Vardas P; University of Crete, Greece.; European Society of Cardiology Health Policy Unit, European Heart Health Institute, Brussels, Belgium., Wood A; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; Cambridge Centre of Artificial Intelligence in Medicine, University of Cambridge, Cambridge, UK., Aboyans V; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.; Department of Cardiology, Dupuytren-2 University Hospital Center, Limoges, France., Vassiliou VS; Department of Cardiology, Norwich Medical School, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK., Visseren FLJ; Department of Vascular Medicine, University Medical Centre Utrecht, The Netherlands., Lopes LR; Institute of Cardiovascular Sciences, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Elliott P; Institute of Cardiovascular Sciences, University College London, London, UK., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Source: European heart journal [Eur Heart J] 2025 Apr 15; Vol. 46 (15), pp. 1372-1383.
Publication Type: Journal Article; Consensus Statement
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive Cardiology
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  Data: <searchLink fieldCode="AU" term="%22Schunkert+H%22">Schunkert H</searchLink>; Department of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum der Technischen Universität München, 80636 Munich, Lazarettstrasse 36, Germany.; Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Di+Angelantonio+E%22">Di Angelantonio E</searchLink>; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; Health Data Science Centre, Human Technopole, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Inouye+M%22">Inouye M</searchLink>; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Patel+RS%22">Patel RS</searchLink>; Institute of Cardiovascular Sciences, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.; National Institute of Health Research Biomedical Research Centre, University College London Hospitals, London, UK.<br /><searchLink fieldCode="AU" term="%22Ripatti+S%22">Ripatti S</searchLink>; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Faculty of Medicine, University of Helsinki, Finland.; Massachusetts General Hospital & Broad Institute of MIT and Harvard, MA, USA.<br /><searchLink fieldCode="AU" term="%22Widen+E%22">Widen E</searchLink>; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sanderson+SC%22">Sanderson SC</searchLink>; Public Health Genomics (PHG) Foundation, Cambridge, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Behavioural Science and Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kaski+JP%22">Kaski JP</searchLink>; Centre for Paediatric Inherited and Rare Cardiovascular Disease, UCL Institute of Cardiovascular Science, London, and Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22McEvoy+JW%22">McEvoy JW</searchLink>; National Institute for Prevention and Cardiovascular Health, University of Galway School of Medicine, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Vardas+P%22">Vardas P</searchLink>; University of Crete, Greece.; European Society of Cardiology Health Policy Unit, European Heart Health Institute, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Wood+A%22">Wood A</searchLink>; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; Cambridge Centre of Artificial Intelligence in Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Aboyans+V%22">Aboyans V</searchLink>; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT-Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.; Department of Cardiology, Dupuytren-2 University Hospital Center, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Vassiliou+VS%22">Vassiliou VS</searchLink>; Department of Cardiology, Norwich Medical School, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Visseren+FLJ%22">Visseren FLJ</searchLink>; Department of Vascular Medicine, University Medical Centre Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lopes+LR%22">Lopes LR</searchLink>; Institute of Cardiovascular Sciences, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Elliott+P%22">Elliott P</searchLink>; Institute of Cardiovascular Sciences, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kavousi+M%22">Kavousi M</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
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