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Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids.

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Title: Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids.
Authors: Patel MN; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Tiwari S; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang Y; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., O'Neill S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Wu J; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Omo-Lamai S; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, USA., Espy C; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Chase LS; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, USA., Majumder A; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Hoffman E; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Shah A; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Sárközy A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Katzen J; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brenner JS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jacob.brenner@pennmedicine.upenn.edu.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA. jacob.brenner@pennmedicine.upenn.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 Jan; Vol. 44 (1), pp. 79-89. Date of Electronic Publication: 2025 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Patel+MN%22">Patel MN</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+S%22">Tiwari S</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22O'Neill+S%22">O'Neill S</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Omo-Lamai+S%22">Omo-Lamai S</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Espy+C%22">Espy C</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chase+LS%22">Chase LS</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Majumder+A%22">Majumder A</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+E%22">Hoffman E</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shah+A%22">Shah A</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sárközy+A%22">Sárközy A</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Katzen+J%22">Katzen J</searchLink>; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pardi+N%22">Pardi N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+JS%22">Brenner JS</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jacob.brenner@pennmedicine.upenn.edu.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA. jacob.brenner@pennmedicine.upenn.edu.
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