The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis.

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Title: The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis.
Authors: Hsieh LT; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Hall BS; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Newcombe J; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Mendum TA; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Varela SS; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Umrania Y; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom., Deery MJ; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom., Shi WQ; Department of Chemistry, Ball State University, Muncie, United States., Diaz-Delgado J; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, United States., Salguero FJ; United Kingdom Health Security Agency, UKHSA-Porton Down, Salisbury, United Kingdom., Simmonds RE; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Source: ELife [Elife] 2025 Feb 06; Vol. 12. Date of Electronic Publication: 2025 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2050-084X
DOI:10.7554/eLife.86931