The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis.
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| Title: | The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis. |
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| Authors: | Hsieh LT; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Hall BS; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Newcombe J; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Mendum TA; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Varela SS; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom., Umrania Y; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom., Deery MJ; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom., Shi WQ; Department of Chemistry, Ball State University, Muncie, United States., Diaz-Delgado J; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, United States., Salguero FJ; United Kingdom Health Security Agency, UKHSA-Porton Down, Salisbury, United Kingdom., Simmonds RE; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom. |
| Source: | ELife [Elife] 2025 Feb 06; Vol. 12. Date of Electronic Publication: 2025 Feb 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39913180 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hsieh+LT%22">Hsieh LT</searchLink>; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hall+BS%22">Hall BS</searchLink>; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Newcombe+J%22">Newcombe J</searchLink>; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mendum+TA%22">Mendum TA</searchLink>; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Varela+SS%22">Varela SS</searchLink>; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Umrania+Y%22">Umrania Y</searchLink>; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Deery+MJ%22">Deery MJ</searchLink>; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shi+WQ%22">Shi WQ</searchLink>; Department of Chemistry, Ball State University, Muncie, United States.<br /><searchLink fieldCode="AU" term="%22Diaz-Delgado+J%22">Diaz-Delgado J</searchLink>; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, United States.<br /><searchLink fieldCode="AU" term="%22Salguero+FJ%22">Salguero FJ</searchLink>; United Kingdom Health Security Agency, UKHSA-Porton Down, Salisbury, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Simmonds+RE%22">Simmonds RE</searchLink>; Discipline of Microbes, Infection & Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101579614%22">ELife</searchLink> [Elife] 2025 Feb 06; Vol. 12. <i>Date of Electronic Publication: </i>2025 Feb 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22eLife+Sciences+Publications%2C+Ltd%22">eLife Sciences Publications, Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101579614 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2050-084X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222050084X%22">2050084X </searchLink><i>NLM ISO Abbreviation: </i>Elife <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39913180 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7554/eLife.86931 Languages: – Code: eng Text: English Titles: – TitleFull: The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hsieh LT – PersonEntity: Name: NameFull: Hall BS – PersonEntity: Name: NameFull: Newcombe J – PersonEntity: Name: NameFull: Mendum TA – PersonEntity: Name: NameFull: Varela SS – PersonEntity: Name: NameFull: Umrania Y – PersonEntity: Name: NameFull: Deery MJ – PersonEntity: Name: NameFull: Shi WQ – PersonEntity: Name: NameFull: Diaz-Delgado J – PersonEntity: Name: NameFull: Salguero FJ – PersonEntity: Name: NameFull: Simmonds RE IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 02 Text: 2025 Feb 06 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2050-084X Numbering: – Type: volume Value: 12 Titles: – TitleFull: ELife Type: main |
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