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Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.

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Title: Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.
Authors: Sivakumar S; Department of Oncology, University of Oxford, Oxford, OX3 7LF, UK. s.sivakumar@bham.ac.uk.; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Dr, Headington, Oxford, OX3 7FY, UK. s.sivakumar@bham.ac.uk.; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK. s.sivakumar@bham.ac.uk., Jainarayanan A; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Dr, Headington, Oxford, OX3 7FY, UK.; Institute of Developmental and Regenerative Medicine (IDRM), Old Road Campus, Old Rd, Roosevelt Dr, Headington, University of Oxford, Oxford, OX3 7TY, UK., Arbe-Barnes E; Oxford University Clinical Academic Graduate School, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.; UCL Institute of Immunity & Transplantation, The Pears Building, Pond Street, London, NW3 2PP, UK., Sharma PK; Department of Oncology, University of Oxford, Oxford, OX3 7LF, UK., Leathlobhair MN; Department of Microbiology, Trinity College, Dublin, Ireland.; Oxford Big Data Institute, Old Road Campus, University of Oxford, Oxford, OX3 7LF, UK., Amin S; Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK., Reiss DJ; Bristol-Myers Squibb, Seattle, Seattle, WA, USA., Heij L; GROW School for Oncology and Developmental Biology, Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany., Hegde S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA., Magen A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA., Tucci F; Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK.; Oxford Cancer Centre, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Sun B; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 7LD, UK., Wu S; Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK.; Oxford Cancer Centre, Oxford, UK., Anand NM; Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK., Slawinski H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Revale S; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nassiri I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Webber J; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Dr, Headington, Oxford, OX3 7FY, UK., Hoeltzel GD; Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK., Frampton AE; Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Daphne Jackson Road, Guildford, GU2 7WG, UK.; Department of Hepato-Pancreato-Biliary (HPB) Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, GU2 7XX, UK.; Targeted Cancer Therapy Unit, Department of Clinical and Experimental Medicine, Faculty of Health and Medical Science, University of Surrey, Guildford, GU2 7WG, UK.; Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK., Wiltberger G; Department of General, Visceral, and Transplantation Surgery, University Hospital of RWTH Aachen, Aachen, Germany., Neumann U; Department of General, Visceral, and Transplantation Surgery, University Hospital of RWTH Aachen, Aachen, Germany.; Department of Surgery Maastricht University Medical Center (MUMC), Maastricht, The Netherlands., Charlton P; Department of Oncology, University of Oxford, Oxford, OX3 7LF, UK., Spiers L; Department of Oncology, University of Oxford, Oxford, OX3 7LF, UK., Elliott T; Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wang M; Bristol-Myers Squibb, Seattle, Seattle, WA, USA., Couto S; Neomorph, Inc., 5590 Morehouse Dr, San Diego, CA, USA., Lila T; Bristol-Myers Squibb, Seattle, Seattle, WA, USA., Sivakumar PV; Bristol-Myers Squibb, Seattle, Seattle, WA, USA., Ratushny AV; Bristol-Myers Squibb, Seattle, Seattle, WA, USA., Middleton MR; Department of Oncology, University of Oxford, Oxford, OX3 7LF, UK., Peppa D; UCL Institute of Immunity & Transplantation, The Pears Building, Pond Street, London, NW3 2PP, UK.; Nuffield Department of Medicine, Old Road Campus, University of Oxford, Oxford, OX3 7BN, UK., Fairfax B; Department of Oncology, University of Oxford, Oxford, OX3 7LF, UK., Merad M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA., Dustin ML; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Dr, Headington, Oxford, OX3 7FY, UK.; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK., Abu-Shah E; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Dr, Headington, Oxford, OX3 7FY, UK. enas.abushah@path.ox.ac.uk.; Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford, OX1 3RE, UK. enas.abushah@path.ox.ac.uk., Bashford-Rogers R; Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK. rachael.bashford-rogers@bioch.ox.ac.uk.; Oxford Cancer Centre, Oxford, UK. rachael.bashford-rogers@bioch.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. rachael.bashford-rogers@bioch.ox.ac.uk.
Source: Nature communications [Nat Commun] 2025 Feb 06; Vol. 16 (1), pp. 1397. Date of Electronic Publication: 2025 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.
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