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TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes-statistical analysis plan for a cluster randomized, cross-sectional, double cross-over, clinical trial.

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Title: TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes-statistical analysis plan for a cluster randomized, cross-sectional, double cross-over, clinical trial.
Authors: Zaloumis S; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Summers MJ; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia., Presneill JJ; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, VIC, Australia., Bellomo R; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia., Chapple LS; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, National Health and Medical Research Council of Australia, University of Adelaide, Adelaide, South Australia, Australia., Chapman MJ; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, National Health and Medical Research Council of Australia, University of Adelaide, Adelaide, South Australia, Australia., Deane AM; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, VIC, Australia., Ferrie S; Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, Australia., French C; Intensive Care Unit, Sunshine Hospital, Melbourne, VIC, Australia., Hurford S; Medical Research Institute of New Zealand, Wellington, New Zealand., Kakho N; Intensive Care Unit, University Hospital Geelong, Geelong, VIC, Australia., Maiden MJ; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, VIC, Australia., O'Connor SN; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia., Peake SL; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia., Ridley EJ; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Dietetics and Nutrition, Alfred Hospital, Melbourne, VIC, Australia., Tran-Duy A; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.; School of Population and Global Health, Centre for Health Policy, The University of Melbourne, MelbourneMelbourne, VIC, Australia., Williams PJ; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia., Young PJ; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Medical Research Institute of New Zealand, Wellington, New Zealand.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand., Karahalios A; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia. emily.karahalios@unimelb.edu.au.; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, VIC, Australia. emily.karahalios@unimelb.edu.au.
Corporate Authors: TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group
Source: Trials [Trials] 2025 Feb 06; Vol. 26 (1), pp. 42. Date of Electronic Publication: 2025 Feb 06.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
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  Data: TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes-statistical analysis plan for a cluster randomized, cross-sectional, double cross-over, clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Zaloumis+S%22">Zaloumis S</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Summers+MJ%22">Summers MJ</searchLink>; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Presneill+JJ%22">Presneill JJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chapple+LS%22">Chapple LS</searchLink>; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, National Health and Medical Research Council of Australia, University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Chapman+MJ%22">Chapman MJ</searchLink>; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, National Health and Medical Research Council of Australia, University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Deane+AM%22">Deane AM</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ferrie+S%22">Ferrie S</searchLink>; Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.; 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Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Ridley+EJ%22">Ridley EJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Dietetics and Nutrition, Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tran-Duy+A%22">Tran-Duy A</searchLink>; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.; School of Population and Global Health, Centre for Health Policy, The University of Melbourne, MelbourneMelbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Williams+PJ%22">Williams PJ</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Young+PJ%22">Young PJ</searchLink>; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Medical Research Institute of New Zealand, Wellington, New Zealand.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Karahalios+A%22">Karahalios A</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia. emily.karahalios@unimelb.edu.au.; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, VIC, Australia. emily.karahalios@unimelb.edu.au.
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