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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data.

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Title: A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data.
Authors: Murrin O; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Mounier N; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Voller B; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Tata L; Research Software Engineering Group, University of Exeter, UK., Gallego-Moll C; Unitat de Suport a la Recerca Metropolitana Nord, Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain., Roso-Llorach A; Unitat de Suport a la Recerca Metropolitana Nord, Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain., Carrasco-Ribelles LA; Unitat de Suport a la Recerca Metropolitana Nord, Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain; Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salut (RICAPPS), Instituto de Salud Carlos III (ISCIII), Avenida Monforte de Lemos, 5, Madrid, 28029, Spain., Fox C; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Allan LM; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Woodward RM; Department of Population Health Sciences, University of Leicester, UK., Liang X; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Valderas JM; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK; Department of Family Medicine, National University Health System, 1E Kent Ridge Road, 119228, Singapore., Khalid SM; Centre for Statistics in Medicine, Nuffield of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, UK., Dudbridge F; Department of Population Health Sciences, University of Leicester, UK., Lamb SE; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Mancini M; Public and Patient involvement representative, UK., Farmer L; Public and Patient involvement representative, UK., Boddy K; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Bowden J; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Melzer D; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Frayling TM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK; Department of Genetic Medicine and Development, Faculty of Medicine, 1 rue Michel-Servet, CH-1211, Genève 4, Switzerland. Electronic address: Timothy.Frayling@unige.ch., Masoli JAH; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK; Royal Devon University Healthcare NHS Foundation Trust, Barrack Road, Exeter, EX2 5DW, UK., Pilling LC; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK., Violán C; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain; Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salut (RICAPPS), Instituto de Salud Carlos III (ISCIII), Avenida Monforte de Lemos, 5, Madrid, 28029, Spain; Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAP Jordi Gol), Mare de Déu de Guadalupe, 2, Mataró, 08303, State, Spain; Germans Trias i Pujol Research Institute (IGTP), Street, Badalona, 08916, State, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Plaça Cívica, 1, Cerdanyola de Vallès, 08193, State, Spain., Delgado J; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK. Electronic address: J.Correa-Delgado@exeter.ac.uk.
Source: EBioMedicine [EBioMedicine] 2025 Mar; Vol. 113, pp. 105584. Date of Electronic Publication: 2025 Feb 06.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data.
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  Data: <searchLink fieldCode="AU" term="%22Murrin+O%22">Murrin O</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Mounier+N%22">Mounier N</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Voller+B%22">Voller B</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Tata+L%22">Tata L</searchLink>; Research Software Engineering Group, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Gallego-Moll+C%22">Gallego-Moll C</searchLink>; Unitat de Suport a la Recerca Metropolitana Nord, Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain.<br /><searchLink fieldCode="AU" term="%22Roso-Llorach+A%22">Roso-Llorach A</searchLink>; Unitat de Suport a la Recerca Metropolitana Nord, Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain.<br /><searchLink fieldCode="AU" term="%22Carrasco-Ribelles+LA%22">Carrasco-Ribelles LA</searchLink>; Unitat de Suport a la Recerca Metropolitana Nord, Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain; Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salut (RICAPPS), Instituto de Salud Carlos III (ISCIII), Avenida Monforte de Lemos, 5, Madrid, 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Fox+C%22">Fox C</searchLink>; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Allan+LM%22">Allan LM</searchLink>; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Woodward+RM%22">Woodward RM</searchLink>; Department of Population Health Sciences, University of Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Valderas+JM%22">Valderas JM</searchLink>; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK; Department of Family Medicine, National University Health System, 1E Kent Ridge Road, 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Khalid+SM%22">Khalid SM</searchLink>; Centre for Statistics in Medicine, Nuffield of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dudbridge+F%22">Dudbridge F</searchLink>; Department of Population Health Sciences, University of Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Lamb+SE%22">Lamb SE</searchLink>; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Mancini+M%22">Mancini M</searchLink>; Public and Patient involvement representative, UK.<br /><searchLink fieldCode="AU" term="%22Farmer+L%22">Farmer L</searchLink>; Public and Patient involvement representative, UK.<br /><searchLink fieldCode="AU" term="%22Boddy+K%22">Boddy K</searchLink>; Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Bowden+J%22">Bowden J</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Melzer+D%22">Melzer D</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Frayling+TM%22">Frayling TM</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK; Department of Genetic Medicine and Development, Faculty of Medicine, 1 rue Michel-Servet, CH-1211, Genève 4, Switzerland. Electronic address: Timothy.Frayling@unige.ch.<br /><searchLink fieldCode="AU" term="%22Masoli+JAH%22">Masoli JAH</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK; Royal Devon University Healthcare NHS Foundation Trust, Barrack Road, Exeter, EX2 5DW, UK.<br /><searchLink fieldCode="AU" term="%22Pilling+LC%22">Pilling LC</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Violán+C%22">Violán C</searchLink>; Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAPJGol), Mare de Déu de Guadalupe, 2, Barcelona, 08303, Spain; Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salut (RICAPPS), Instituto de Salud Carlos III (ISCIII), Avenida Monforte de Lemos, 5, Madrid, 28029, Spain; Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primaria Jordi Gol (IDIAP Jordi Gol), Mare de Déu de Guadalupe, 2, Mataró, 08303, State, Spain; Germans Trias i Pujol Research Institute (IGTP), Street, Badalona, 08916, State, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Plaça Cívica, 1, Cerdanyola de Vallès, 08193, State, Spain.<br /><searchLink fieldCode="AU" term="%22Delgado+J%22">Delgado J</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, UK. Electronic address: J.Correa-Delgado@exeter.ac.uk.
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