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Beneficial and harmful effects of duloxetine versus placebo, 'active placebo' or no intervention for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.

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Title: Beneficial and harmful effects of duloxetine versus placebo, 'active placebo' or no intervention for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.
Authors: Siddiqui F; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark faiza.siddiqui@ctu.dk., Petersen JJ; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark., Juul S; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Stolpegaard Psychotherapy Centre, Mental Health Services, The Capital Region, Gentofte, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark., Kamp CB; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark., Barbateskovic M; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark., Moncrieff J; Division of Psychiatry, University College London, London, UK.; Research and Development Department, North East London NHS Foundation Trust (NELFT), Essex, UK., Horowitz MA; Research and Development Department, North East London NHS Foundation Trust (NELFT), Essex, UK.; (honorary position for MAH) Division of Psychiatry, University College London, London, UK., Maagaard M; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Katakam KK; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark., Gluud C; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark.
Source: BMJ open [BMJ Open] 2025 Feb 07; Vol. 15 (2), pp. e082853. Date of Electronic Publication: 2025 Feb 07.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Beneficial and harmful effects of duloxetine versus placebo, 'active placebo' or no intervention for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.
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  Data: <searchLink fieldCode="AU" term="%22Siddiqui+F%22">Siddiqui F</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark faiza.siddiqui@ctu.dk.<br /><searchLink fieldCode="AU" term="%22Petersen+JJ%22">Petersen JJ</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Juul+S%22">Juul S</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Stolpegaard Psychotherapy Centre, Mental Health Services, The Capital Region, Gentofte, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kamp+CB%22">Kamp CB</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Barbateskovic+M%22">Barbateskovic M</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Moncrieff+J%22">Moncrieff J</searchLink>; Division of Psychiatry, University College London, London, UK.; Research and Development Department, North East London NHS Foundation Trust (NELFT), Essex, UK.<br /><searchLink fieldCode="AU" term="%22Horowitz+MA%22">Horowitz MA</searchLink>; Research and Development Department, North East London NHS Foundation Trust (NELFT), Essex, UK.; (honorary position for MAH) Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Maagaard+M%22">Maagaard M</searchLink>; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Katakam+KK%22">Katakam KK</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gluud+C%22">Gluud C</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+JC%22">Jakobsen JC</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital ─ Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Heath Sciences, University of Southern Denmark, Odense, Denmark.
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