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CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial.

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Title: CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial.
Authors: Reiss KA; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA., Angelos MG; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA., Dees EC; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Yuan Y; City of Hope Cancer Center, Duarte, CA, USA.; Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ueno NT; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; University of Hawai'i Cancer Center, Honolulu, HI, USA., Pohlmann PR; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johnson ML; Sarah Cancer Research Institute, Nashville, TN, USA., Chao J; City of Hope Cancer Center, Duarte, CA, USA., Shestova O; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA., Serody JS; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Schmierer M; Carisma Therapeutics, Philadelphia, PA, USA., Kremp M; Carisma Therapeutics, Philadelphia, PA, USA., Ball M; Carisma Therapeutics, Philadelphia, PA, USA., Qureshi R; Carisma Therapeutics, Philadelphia, PA, USA., Schott BH; Carisma Therapeutics, Philadelphia, PA, USA., Sonawane P; Carisma Therapeutics, Philadelphia, PA, USA., DeLong SC; Carisma Therapeutics, Philadelphia, PA, USA., Christiano M; Carisma Therapeutics, Philadelphia, PA, USA., Swaby RF; Carisma Therapeutics, Philadelphia, PA, USA., Abramson S; Carisma Therapeutics, Philadelphia, PA, USA., Locke K; Carisma Therapeutics, Philadelphia, PA, USA., Barton D; Carisma Therapeutics, Philadelphia, PA, USA., Kennedy E; Carisma Therapeutics, Philadelphia, PA, USA., Gill S; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA., Cushing D; Carisma Therapeutics, Philadelphia, PA, USA., Klichinsky M; Carisma Therapeutics, Philadelphia, PA, USA., Condamine T; Carisma Therapeutics, Philadelphia, PA, USA. Thomas.Condamine@carismatx.com., Abdou Y; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Source: Nature medicine [Nat Med] 2025 Apr; Vol. 31 (4), pp. 1171-1182. Date of Electronic Publication: 2025 Feb 07.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Reiss+KA%22">Reiss KA</searchLink>; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Angelos+MG%22">Angelos MG</searchLink>; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dees+EC%22">Dees EC</searchLink>; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; City of Hope Cancer Center, Duarte, CA, USA.; Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ueno+NT%22">Ueno NT</searchLink>; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; University of Hawai'i Cancer Center, Honolulu, HI, USA.<br /><searchLink fieldCode="AU" term="%22Pohlmann+PR%22">Pohlmann PR</searchLink>; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+ML%22">Johnson ML</searchLink>; Sarah Cancer Research Institute, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chao+J%22">Chao J</searchLink>; City of Hope Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shestova+O%22">Shestova O</searchLink>; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Serody+JS%22">Serody JS</searchLink>; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Schmierer+M%22">Schmierer M</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kremp+M%22">Kremp M</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ball+M%22">Ball M</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Qureshi+R%22">Qureshi R</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Schott+BH%22">Schott BH</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sonawane+P%22">Sonawane P</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22DeLong+SC%22">DeLong SC</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Christiano+M%22">Christiano M</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Swaby+RF%22">Swaby RF</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Abramson+S%22">Abramson S</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Locke+K%22">Locke K</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Barton+D%22">Barton D</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+E%22">Kennedy E</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gill+S%22">Gill S</searchLink>; University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cushing+D%22">Cushing D</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Klichinsky+M%22">Klichinsky M</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Condamine+T%22">Condamine T</searchLink>; Carisma Therapeutics, Philadelphia, PA, USA. Thomas.Condamine@carismatx.com.<br /><searchLink fieldCode="AU" term="%22Abdou+Y%22">Abdou Y</searchLink>; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Apr; Vol. 31 (4), pp. 1171-1182. <i>Date of Electronic Publication: </i>2025 Feb 07.
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