Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data.

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Title: Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data.
Authors: Shiomi Y; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.; Department of Neurology, Keio University School of Medicine, Tokyo, Japan., Miwa K; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan., Jensen M; Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Inoue M; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan., Yoshimura S; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan., Kamogawa N; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan., Fukuda-Doi M; Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan., Ma H; Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia., Ringleb P; Department of Neurology, University of Heidelberg, Heidelberg, Germany., Wu O; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA., Schwamm LH; Yale School of Medicine, New Haven, CT, USA., Davis SM; Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia., Donnan GA; Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia., Gerloff C; Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Nakahara J; Department of Neurology, Keio University School of Medicine, Tokyo, Japan., Toyoda K; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.; Department of Neurology, Keio University School of Medicine, Tokyo, Japan., Thomalla G; Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Koga M; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Source: International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2025 Jul; Vol. 20 (6), pp. 679-686. Date of Electronic Publication: 2025 Feb 27.
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE
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  Data: Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data.
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  Data: <searchLink fieldCode="AU" term="%22Shiomi+Y%22">Shiomi Y</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miwa+K%22">Miwa K</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Jensen+M%22">Jensen M</searchLink>; Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Inoue+M%22">Inoue M</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimura+S%22">Yoshimura S</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Kamogawa+N%22">Kamogawa N</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda-Doi+M%22">Fukuda-Doi M</searchLink>; Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ringleb+P%22">Ringleb P</searchLink>; Department of Neurology, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+O%22">Wu O</searchLink>; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schwamm+LH%22">Schwamm LH</searchLink>; Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Davis+SM%22">Davis SM</searchLink>; Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Donnan+GA%22">Donnan GA</searchLink>; Departments of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gerloff+C%22">Gerloff C</searchLink>; Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nakahara+J%22">Nakahara J</searchLink>; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Toyoda+K%22">Toyoda K</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Thomalla+G%22">Thomalla G</searchLink>; Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Koga+M%22">Koga M</searchLink>; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101274068%22">International journal of stroke : official journal of the International Stroke Society</searchLink> [Int J Stroke] 2025 Jul; Vol. 20 (6), pp. 679-686. <i>Date of Electronic Publication: </i>2025 Feb 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274068 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1747-4949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217474930%22">17474930 </searchLink><i>NLM ISO Abbreviation: </i>Int J Stroke <i>Subsets: </i>MEDLINE
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