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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies in patients with active Crohn's disease.

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Title: A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies in patients with active Crohn's disease.
Authors: Sanderson J; Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK., Aboagye J; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Makinson R; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Rapi K; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Provstgaard-Morys S; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Stockdale L; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Alison Lawrie; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Lanigan I; Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK., Halim N; Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK., Douiri A; Kings College London, Great Maze Pond, London SE1 1UL, UK., Greenlay E; Kings College London, Great Maze Pond, London SE1 1UL, UK., Malek R; Kings College London, Great Maze Pond, London SE1 1UL, UK., Gray E; Kings College London, Great Maze Pond, London SE1 1UL, UK., West L; Kings College London, Great Maze Pond, London SE1 1UL, UK., El Oulidi F; HAV Vaccines Limited, Np-105, Icentre, Howard Way, Newport Pagnell, Milton Keynes MK16 9PY, UK., Cross PI; HAV Vaccines Limited, Np-105, Icentre, Howard Way, Newport Pagnell, Milton Keynes MK16 9PY, UK. Electronic address: paul@pauliancross.com., Stallibrass M; HAV Vaccines Limited, Np-105, Icentre, Howard Way, Newport Pagnell, Milton Keynes MK16 9PY, UK., Gilbert SC; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Hill AVS; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK., Ewer KJ; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.
Source: EBioMedicine [EBioMedicine] 2025 Mar; Vol. 113, pp. 105570. Date of Electronic Publication: 2025 Feb 07.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies in patients with active Crohn's disease.
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  Data: <searchLink fieldCode="AU" term="%22Sanderson+J%22">Sanderson J</searchLink>; Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Aboagye+J%22">Aboagye J</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Makinson+R%22">Makinson R</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Rapi+K%22">Rapi K</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Provstgaard-Morys+S%22">Provstgaard-Morys S</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Stockdale+L%22">Stockdale L</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Alison+Lawrie%22">Alison Lawrie</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Lanigan+I%22">Lanigan I</searchLink>; Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Halim+N%22">Halim N</searchLink>; Guy's and St Thomas' Hospitals NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Douiri+A%22">Douiri A</searchLink>; Kings College London, Great Maze Pond, London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22Greenlay+E%22">Greenlay E</searchLink>; Kings College London, Great Maze Pond, London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22Malek+R%22">Malek R</searchLink>; Kings College London, Great Maze Pond, London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22Gray+E%22">Gray E</searchLink>; Kings College London, Great Maze Pond, London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22West+L%22">West L</searchLink>; Kings College London, Great Maze Pond, London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22El+Oulidi+F%22">El Oulidi F</searchLink>; HAV Vaccines Limited, Np-105, Icentre, Howard Way, Newport Pagnell, Milton Keynes MK16 9PY, UK.<br /><searchLink fieldCode="AU" term="%22Cross+PI%22">Cross PI</searchLink>; HAV Vaccines Limited, Np-105, Icentre, Howard Way, Newport Pagnell, Milton Keynes MK16 9PY, UK. Electronic address: paul@pauliancross.com.<br /><searchLink fieldCode="AU" term="%22Stallibrass+M%22">Stallibrass M</searchLink>; HAV Vaccines Limited, Np-105, Icentre, Howard Way, Newport Pagnell, Milton Keynes MK16 9PY, UK.<br /><searchLink fieldCode="AU" term="%22Gilbert+SC%22">Gilbert SC</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; The Jenner Institute, ORCRB, University of Oxford, Oxford, OX3 7DQ, UK.
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  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2025 Mar; Vol. 113, pp. 105570. <i>Date of Electronic Publication: </i>2025 Feb 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101647039 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3964 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523964%22">23523964 </searchLink><i>NLM ISO Abbreviation: </i>EBioMedicine <i>Subsets: </i>MEDLINE
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