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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.

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Title: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
Authors: Hoffmann TJ; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Graff RE; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Madduri RK; Data Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA., Rodriguez AA; Data Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA., Cario CL; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA., Feng K; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Jiang Y; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA., Wang A; Center for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Klein RJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pierce BL; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.; Department of Human Genetics, University of Chicago, Chicago, IL, USA.; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA., Eggener S; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA.; Department of Urology, University of Chicago, Chicago, IL, USA.; Department of Surgery, University of Chicago, Chicago, IL, USA., Tong L; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Blot W; Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Long J; Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Goss LB; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Darst BF; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Rebbeck T; Dana Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Lachance J; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Andrews C; Dana Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Adebiyi AO; Department of Community Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Adusei B; 37 Military Hospital, Accra, Ghana., Aisuodionoe-Shadrach OI; College of Health Sciences, University of Abuja, Abuja, Nigeria.; Cancer Science Centre Abuja, Abuja, Nigeria.; University of Abuja Teaching Hospital, Abuja, Nigeria., Fernandez PW; Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Jalloh M; Hospital General Idrissa Pouye, Dakar, Senegal.; Ecole Doctorale, Universite Iba Der Thiam de Thies, Thies, Senegal., Janivara R; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Chen WC; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa., Mensah JE; Korle-Bu Teaching Hospital and University of Ghana Medical School, Accra, Ghana., Agalliu I; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.; Department of Urology, Albert Einstein College of Medicine, New York, NY, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Shelley JP; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Schaffer K; Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Freedman ND; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Li SA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Goodman PJ; SWOG Statistics and Data Management Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Till C; SWOG Statistics and Data Management Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Thompson I; CHRISTUS Santa Rosa Medical Center Hospital, San Antonio, TX, USA., Lilja H; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Translational Medicine, Lund University, Malmö, Sweden.; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ranatunga DK; Kaiser Permanente Research Bank, Oakland, CA, USA., Presti J; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Van Den Eeden SK; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Mosley JD; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Conti DV; Center for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Haiman CA; Center for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Justice AC; Veterans Administration Connecticut Healthcare System, West Haven, CT, USA.; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Yale University School of Public Health, Yale School of Medicine, New Haven, CT, USA., Kachuri L; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. lkachuri@stanford.edu.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. lkachuri@stanford.edu., Witte JS; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. jswitte@stanford.edu.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA. jswitte@stanford.edu.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. jswitte@stanford.edu.; Department of Genetics, Stanford University, Stanford, CA, USA. jswitte@stanford.edu.
Source: Nature genetics [Nat Genet] 2025 Feb; Vol. 57 (2), pp. 334-344. Date of Electronic Publication: 2025 Feb 10.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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