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Optimizing Triglyceride Prodrugs of a Model Immunomodulator: Conjugation through the Phenol of Mycophenolic Acid (MPA) Markedly Promotes Lymphatic Drug Transport.

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Title: Optimizing Triglyceride Prodrugs of a Model Immunomodulator: Conjugation through the Phenol of Mycophenolic Acid (MPA) Markedly Promotes Lymphatic Drug Transport.
Authors: Hu L, Quach T; Seaport Therapeutics, 6 Tide Street, Boston, Massachusetts 02210, United States., Zheng D, Leong NJ, Sharma G, Lim SF, Bonner D; Seaport Therapeutics, 6 Tide Street, Boston, Massachusetts 02210, United States., Trevaskis NL, Simpson JS; Seaport Therapeutics, 6 Tide Street, Boston, Massachusetts 02210, United States., Han S, Porter CJH
Source: Molecular pharmaceutics [Mol Pharm] 2025 Mar 03; Vol. 22 (3), pp. 1555-1567. Date of Electronic Publication: 2025 Feb 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink><br /><searchLink fieldCode="AU" term="%22Quach+T%22">Quach T</searchLink>; Seaport Therapeutics, 6 Tide Street, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Zheng+D%22">Zheng D</searchLink><br /><searchLink fieldCode="AU" term="%22Leong+NJ%22">Leong NJ</searchLink><br /><searchLink fieldCode="AU" term="%22Sharma+G%22">Sharma G</searchLink><br /><searchLink fieldCode="AU" term="%22Lim+SF%22">Lim SF</searchLink><br /><searchLink fieldCode="AU" term="%22Bonner+D%22">Bonner D</searchLink>; Seaport Therapeutics, 6 Tide Street, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Trevaskis+NL%22">Trevaskis NL</searchLink><br /><searchLink fieldCode="AU" term="%22Simpson+JS%22">Simpson JS</searchLink>; Seaport Therapeutics, 6 Tide Street, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink><br /><searchLink fieldCode="AU" term="%22Porter+CJH%22">Porter CJH</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101197791%22">Molecular pharmaceutics</searchLink> [Mol Pharm] 2025 Mar 03; Vol. 22 (3), pp. 1555-1567. <i>Date of Electronic Publication: </i>2025 Feb 11.
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        Value: 10.1021/acs.molpharmaceut.4c01272
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              Text: 2025 Mar 03
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