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Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes.

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Title: Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes.
Authors: Rust LN; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Wettengel JM; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich 81675, Germany.; German Center for Infection Research, Munich Partner Site, Munich 81675, Germany., Biswas S; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Ryu J; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Piekarski N; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Yusova S; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Lutz SS; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Naldiga S; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Hinrichs BJ; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Sullivan MN; Division of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Lo JO; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich 81675, Germany.; German Center for Infection Research, Munich Partner Site, Munich 81675, Germany., Smedley JV; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Sacha JB; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Hanna CB; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Bimber BN; Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Hennebold JD; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006., Burwitz BJ; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.; Division of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Feb 18; Vol. 122 (7), pp. e2413771122. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes.
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  Data: <searchLink fieldCode="AU" term="%22Rust+LN%22">Rust LN</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Wettengel+JM%22">Wettengel JM</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich 81675, Germany.; German Center for Infection Research, Munich Partner Site, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Biswas+S%22">Biswas S</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Ryu+J%22">Ryu J</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Piekarski+N%22">Piekarski N</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Yusova+S%22">Yusova S</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Lutz+SS%22">Lutz SS</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Naldiga+S%22">Naldiga S</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Hinrichs+BJ%22">Hinrichs BJ</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Sullivan+MN%22">Sullivan MN</searchLink>; Division of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Lo+JO%22">Lo JO</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Protzer+U%22">Protzer U</searchLink>; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich 81675, Germany.; German Center for Infection Research, Munich Partner Site, Munich 81675, Germany.<br /><searchLink fieldCode="AU" term="%22Smedley+JV%22">Smedley JV</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Sacha+JB%22">Sacha JB</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Hanna+CB%22">Hanna CB</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Bimber+BN%22">Bimber BN</searchLink>; Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Hennebold+JD%22">Hennebold JD</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.<br /><searchLink fieldCode="AU" term="%22Burwitz+BJ%22">Burwitz BJ</searchLink>; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.; Division of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Feb 18; Vol. 122 (7), pp. e2413771122. <i>Date of Electronic Publication: </i>2025 Feb 12.
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