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Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies.

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Title: Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies.
Authors: Ketaren NE; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: nketaren@rockefeller.edu., Fridy PC; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA., Malashkevich V; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Sanyal T; Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA., Brillantes M; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA., Thompson MK; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA., Oren DA; Structural Biology Resource Center, The Rockefeller University, New York, NY 10065, USA., Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Šali A; Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Chait BT; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA., Rout MP; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: rout@rockefeller.edu.
Source: Structure (London, England : 1993) [Structure] 2025 Apr 03; Vol. 33 (4), pp. 677-690.e5. Date of Electronic Publication: 2025 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies.
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  Data: <searchLink fieldCode="AU" term="%22Ketaren+NE%22">Ketaren NE</searchLink>; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: nketaren@rockefeller.edu.<br /><searchLink fieldCode="AU" term="%22Fridy+PC%22">Fridy PC</searchLink>; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Malashkevich+V%22">Malashkevich V</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Sanyal+T%22">Sanyal T</searchLink>; Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Brillantes+M%22">Brillantes M</searchLink>; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+MK%22">Thompson MK</searchLink>; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Oren+DA%22">Oren DA</searchLink>; Structural Biology Resource Center, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Bonanno+JB%22">Bonanno JB</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Šali+A%22">Šali A</searchLink>; Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Almo+SC%22">Almo SC</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Chait+BT%22">Chait BT</searchLink>; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Rout+MP%22">Rout MP</searchLink>; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: rout@rockefeller.edu.
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  Data: <searchLink fieldCode="JN" term="%22101087697%22">Structure (London, England : 1993)</searchLink> [Structure] 2025 Apr 03; Vol. 33 (4), pp. 677-690.e5. <i>Date of Electronic Publication: </i>2025 Feb 11.
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