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PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma.

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Title: PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma.
Authors: Stewart J; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.; Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, UK and Division of Clinical Studies, Institute of Cancer Research, London, UK., Krastev DB; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Brough R; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Zatreanu D; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Song F; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Baxter JS; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Sridhar S; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Frankum J; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Konde A; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Yang W; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Haider S; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Alexander J; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Betteridge K; Light microscopy Facility, The Institute of Cancer Research, London, SW3 6JB, UK., Gulati A; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Attygalle AD; Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, UK and Division of Clinical Studies, Institute of Cancer Research, London, UK., Vroobel K; Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, UK and Division of Clinical Studies, Institute of Cancer Research, London, UK., Natrajan R; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Khalique S; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.; Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, UK and Division of Clinical Studies, Institute of Cancer Research, London, UK., Roumeliotis TI; Functional Proteomics Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK., Choudhary JS; Functional Proteomics Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK., Yeung J; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Wicks AJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Marlow R; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Banerjee S; Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, UK and Division of Clinical Studies, Institute of Cancer Research, London, UK., Pettitt SJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Tutt ANJ; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Lord CJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK. chris.lord@icr.ac.uk.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. chris.lord@icr.ac.uk.
Source: Oncogene [Oncogene] 2025 Mar; Vol. 44 (9), pp. 618-629. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Marlow+R%22">Marlow R</searchLink>; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Banerjee+S%22">Banerjee S</searchLink>; Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, UK and Division of Clinical Studies, Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Pettitt+SJ%22">Pettitt SJ</searchLink>; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, UK.; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Tutt+ANJ%22">Tutt ANJ</searchLink>; Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Lord+CJ%22">Lord CJ</searchLink>; 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