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Optimising Aripiprazole Long-Acting Injectable: A Comparative Study of One- and Two-Injection Start Regimens in Schizophrenia with and Without Substance Use Disorders and Relationship to Early Serum Levels.

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Title: Optimising Aripiprazole Long-Acting Injectable: A Comparative Study of One- and Two-Injection Start Regimens in Schizophrenia with and Without Substance Use Disorders and Relationship to Early Serum Levels.
Authors: Trovini G; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Molecular and Developmental Medicine, Division of Psychiatry, School of Medicine, University of Siena, 53100 Siena, Italy., Lombardozzi G; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy., Kotzalidis GD; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, LargoAgostino Gemelli 8, 00168 Rome, Italy.; Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy., Lionetto L; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy., Russo F; SPDC DSM ASL BA (SPDC Ospedale Santa Maria Degli Angeli), P.za Padre Pio 21, 70017 Putignano, Italy., Sabatino A; DSM ASL Viterbo Distretto C (CSM Civita Castellana), via Francesco Petrarca snc, 01033 Civita Castellana, Italy., Serra E; Azienda Sanitaria Locale Lecce, UOC CSM Nardò, Via XXV Luglio, 4, 73048 Nardò, Italy., Castorina S; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Mental, Neurological, Dental and Sensory Organ Wellbeing, Fondazione PTV-Policlinico Tor Vergata, Tor Vergata University Hospital, Viale Oxford, 81, 00133 Rome, Italy., Civita G; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy., Frezza S; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy., De Bernardini D; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy., Costanzi G; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy., Alborghetti M; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, University of Rome 'La Sapienza', Via di Grottarossa 1035-1039, 00189 Rome, Italy., Simmaco M; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, University of Rome 'La Sapienza', Via di Grottarossa 1035-1039, 00189 Rome, Italy., Nicoletti F; Department of Physiology and Pharmacology 'Vittorio Erspamer', Faculty of Medicine and Pharmacy, University of Rome 'La Sapienza', Piazzale Aldo Moro 5, 00185 Rome, Italy.; IRCCS Neuromed, Pozzilli, Via Atinense, 18, 86077 Pozzilli, Italy., De Filippis S; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.
Source: International journal of molecular sciences [Int J Mol Sci] 2025 Feb 06; Vol. 26 (3). Date of Electronic Publication: 2025 Feb 06.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Optimising Aripiprazole Long-Acting Injectable: A Comparative Study of One- and Two-Injection Start Regimens in Schizophrenia with and Without Substance Use Disorders and Relationship to Early Serum Levels.
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  Data: <searchLink fieldCode="AU" term="%22Trovini+G%22">Trovini G</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Molecular and Developmental Medicine, Division of Psychiatry, School of Medicine, University of Siena, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Lombardozzi+G%22">Lombardozzi G</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Kotzalidis+GD%22">Kotzalidis GD</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, LargoAgostino Gemelli 8, 00168 Rome, Italy.; Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lionetto+L%22">Lionetto L</searchLink>; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+F%22">Russo F</searchLink>; SPDC DSM ASL BA (SPDC Ospedale Santa Maria Degli Angeli), P.za Padre Pio 21, 70017 Putignano, Italy.<br /><searchLink fieldCode="AU" term="%22Sabatino+A%22">Sabatino A</searchLink>; DSM ASL Viterbo Distretto C (CSM Civita Castellana), via Francesco Petrarca snc, 01033 Civita Castellana, Italy.<br /><searchLink fieldCode="AU" term="%22Serra+E%22">Serra E</searchLink>; Azienda Sanitaria Locale Lecce, UOC CSM Nardò, Via XXV Luglio, 4, 73048 Nardò, Italy.<br /><searchLink fieldCode="AU" term="%22Castorina+S%22">Castorina S</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Mental, Neurological, Dental and Sensory Organ Wellbeing, Fondazione PTV-Policlinico Tor Vergata, Tor Vergata University Hospital, Viale Oxford, 81, 00133 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Civita+G%22">Civita G</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Frezza+S%22">Frezza S</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Bernardini+D%22">De Bernardini D</searchLink>; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Costanzi+G%22">Costanzi G</searchLink>; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Alborghetti+M%22">Alborghetti M</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, University of Rome 'La Sapienza', Via di Grottarossa 1035-1039, 00189 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Simmaco+M%22">Simmaco M</searchLink>; Clinical Biochemistry, Mass Spectrometry Section, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.; Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, University of Rome 'La Sapienza', Via di Grottarossa 1035-1039, 00189 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nicoletti+F%22">Nicoletti F</searchLink>; Department of Physiology and Pharmacology 'Vittorio Erspamer', Faculty of Medicine and Pharmacy, University of Rome 'La Sapienza', Piazzale Aldo Moro 5, 00185 Rome, Italy.; IRCCS Neuromed, Pozzilli, Via Atinense, 18, 86077 Pozzilli, Italy.<br /><searchLink fieldCode="AU" term="%22De+Filippis+S%22">De Filippis S</searchLink>; Clinica Villa von Siebenthal Neuropsychiatric Hospital, Via della Madonnina 1, 00040 Rome, Italy.
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