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Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).

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Title: Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).
Authors: Monsen PJ; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Bommi PV; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Grigorescu AA; Department of Molecular Biosciences, Northwestern University Weinberg College of Arts and Sciences, Evanston, Illinois 60208, United States., Lauing KL; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Mao Y; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States., Berardi P; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Zhai L; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Ojo O; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Penco-Campillo M; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Koch T; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Egozi M; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Jha S; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Dunne SF; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States., Jiang H; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China., Song G; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China., Zhang F; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China., Kregel S; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States., Vaziri-Gohar A; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.; Department of Surgery, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Fanning SW; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Sanchez-Gomez P; Neuro-Oncology Unit, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Madrid 28029, Spain., Allen JM; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States., Yamini B; Department of Neurological Surgery, University of Chicago Medicine, Chicago, Illinois 60637, United States., Lukas RV; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States., Wainwright DA; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.; Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois 60153, United States., Schiltz GE; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, United States.; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Feb 27; Vol. 68 (4), pp. 4961-4987. Date of Electronic Publication: 2025 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Monsen+PJ%22">Monsen PJ</searchLink>; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Bommi+PV%22">Bommi PV</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Grigorescu+AA%22">Grigorescu AA</searchLink>; Department of Molecular Biosciences, Northwestern University Weinberg College of Arts and Sciences, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Lauing+KL%22">Lauing KL</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Mao+Y%22">Mao Y</searchLink>; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Berardi+P%22">Berardi P</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Zhai+L%22">Zhai L</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Ojo+O%22">Ojo O</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Penco-Campillo+M%22">Penco-Campillo M</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Koch+T%22">Koch T</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Egozi+M%22">Egozi M</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Jha+S%22">Jha S</searchLink>; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Dunne+SF%22">Dunne SF</searchLink>; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China.<br /><searchLink fieldCode="AU" term="%22Song+G%22">Song G</searchLink>; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China.<br /><searchLink fieldCode="AU" term="%22Kregel+S%22">Kregel S</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Vaziri-Gohar+A%22">Vaziri-Gohar A</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.; Department of Surgery, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Fanning+SW%22">Fanning SW</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Sanchez-Gomez+P%22">Sanchez-Gomez P</searchLink>; Neuro-Oncology Unit, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Allen+JM%22">Allen JM</searchLink>; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.<br /><searchLink fieldCode="AU" term="%22Yamini+B%22">Yamini B</searchLink>; Department of Neurological Surgery, University of Chicago Medicine, Chicago, Illinois 60637, United States.<br /><searchLink fieldCode="AU" term="%22Lukas+RV%22">Lukas RV</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.<br /><searchLink fieldCode="AU" term="%22Wainwright+DA%22">Wainwright DA</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.; Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois 60153, United States.<br /><searchLink fieldCode="AU" term="%22Schiltz+GE%22">Schiltz GE</searchLink>; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.; 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Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, United States.; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Feb 27; Vol. 68 (4), pp. 4961-4987. <i>Date of Electronic Publication: </i>2025 Feb 13.
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