Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).
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| Title: | Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). |
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| Authors: | Monsen PJ; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Bommi PV; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Grigorescu AA; Department of Molecular Biosciences, Northwestern University Weinberg College of Arts and Sciences, Evanston, Illinois 60208, United States., Lauing KL; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Mao Y; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States., Berardi P; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Zhai L; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Ojo O; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Penco-Campillo M; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Koch T; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Egozi M; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Jha S; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Dunne SF; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States., Jiang H; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China., Song G; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China., Zhang F; HD Biosciences (China) Co., Ltd., A WuXi AppTec Company, Shanghai 201201, China., Kregel S; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States., Vaziri-Gohar A; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.; Department of Surgery, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Fanning SW; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States., Sanchez-Gomez P; Neuro-Oncology Unit, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Madrid 28029, Spain., Allen JM; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States., Yamini B; Department of Neurological Surgery, University of Chicago Medicine, Chicago, Illinois 60637, United States., Lukas RV; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States., Wainwright DA; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, United States.; Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, United States.; Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois 60153, United States., Schiltz GE; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, United States.; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Feb 27; Vol. 68 (4), pp. 4961-4987. Date of Electronic Publication: 2025 Feb 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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