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LMNA R482L mutation causes impairments in C2C12 myoblasts subpopulations, alterations in metabolic reprogramming during differentiation, and oxidative stress.

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Title: LMNA R482L mutation causes impairments in C2C12 myoblasts subpopulations, alterations in metabolic reprogramming during differentiation, and oxidative stress.
Authors: Ivanova OA; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia. oksana.ivanova.al@gmail.com.; Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia. oksana.ivanova.al@gmail.com., Predeus AV; Bioinformatics Institute, 2A Kantemirovskaya St., Saint Petersburg, 194100, Russia., Sorokina MY; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia.; Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia., Ignatieva EV; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia.; Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia., Bobkov DE; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia.; Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Av., Saint Petersburg, 194064, Russia., Sukhareva KS; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia.; Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia., Kostareva AA; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia.; Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia., Dmitrieva RI; Research Centre for Personalized Medicine, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia. renata.i.dmitrieva@gmail.com.; Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, 2 Akkuratova St., Saint Petersburg, 197341, Russia. renata.i.dmitrieva@gmail.com.
Source: Scientific reports [Sci Rep] 2025 Feb 13; Vol. 15 (1), pp. 5358. Date of Electronic Publication: 2025 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-88219-6