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Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.

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Title: Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.
Authors: Wen S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Kuri-Morales P; Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico., Hu F; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Nag A; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Tachmazidou I; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Deevi SVV; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Taiy H; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Smith KR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Loesch DP; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Burren OS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Dhindsa RS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA., Wasilewski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Alegre-Díaz J; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Ciudad de México, Mexico., Berumen J; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Ciudad de México, Mexico., Emberson J; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Torres JM; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Collins R; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Carss K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wang Q; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Tapia-Conyer R; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Ciudad de México, Mexico., Fabre MA; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Harper AR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vassiliou GS; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. gsv20@cam.ac.uk., Mitchell J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. jonathan.mitchell@astrazeneca.com.
Source: Nature genetics [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 572-582. Date of Electronic Publication: 2025 Feb 13.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.
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  Data: <searchLink fieldCode="AU" term="%22Wen+S%22">Wen S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kuri-Morales+P%22">Kuri-Morales P</searchLink>; Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Nag+A%22">Nag A</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tachmazidou+I%22">Tachmazidou I</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Deevi+SVV%22">Deevi SVV</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Taiy+H%22">Taiy H</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Smith+KR%22">Smith KR</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Loesch+DP%22">Loesch DP</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Burren+OS%22">Burren OS</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dhindsa+RS%22">Dhindsa RS</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wasilewski+S%22">Wasilewski S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Alegre-Díaz+J%22">Alegre-Díaz J</searchLink>; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Ciudad de México, Mexico.<br /><searchLink fieldCode="AU" term="%22Berumen+J%22">Berumen J</searchLink>; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Ciudad de México, Mexico.<br /><searchLink fieldCode="AU" term="%22Emberson+J%22">Emberson J</searchLink>; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Torres+JM%22">Torres JM</searchLink>; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Collins+R%22">Collins R</searchLink>; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Carss+K%22">Carss K</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Petrovski+S%22">Petrovski S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tapia-Conyer+R%22">Tapia-Conyer R</searchLink>; Faculty of Medicine, National Autonomous University of Mexico, Copilco Universidad, Ciudad de México, Mexico.<br /><searchLink fieldCode="AU" term="%22Fabre+MA%22">Fabre MA</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Harper+AR%22">Harper AR</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. gsv20@cam.ac.uk.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. gsv20@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Mitchell+J%22">Mitchell J</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. jonathan.mitchell@astrazeneca.com.
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