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Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.

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Title: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.
Authors: Coleman AE; Department of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA. mericksn@uga.edu., Creevy KE; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Anderson R; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; GRECC William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Reed MJ; Department of Medicine, University of Washington, Seattle, WA, USA., Fajt VR; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA., Aicher KM; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Atiee G; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Barnett BG; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Baumwart RD; Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA., Boudreau B; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Cunningham SM; Department of Clinical Sciences, Tufts University, North Grafton, MA, USA., Dunbar MD; Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, USA., Ditzler B; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Ferguson AM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Forsyth KK; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Gambino AN; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Gordon SG; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Hammond HK; Department of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA., Holland SN; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Iannaccone MK; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Illing K; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Kadotani S; Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA., Knowles SA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., MacLean EL; College of Veterinary Medicine, University of Arizona, Tucson, AZ, USA., Maran BA; Olympic Veterinary Cardiology, Everett, WA, USA., Markovic LE; Department of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA., McGrath S; Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA., Melvin RL; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Mueller MS; Olympic Veterinary Cardiology, Everett, WA, USA., Nelson OL; Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA., Olby NJ; Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA., Pancotto TE; Specialists in Companion Animal Neurology, Naples, FL, USA., Parsley E; Department of Clinical Sciences, Tufts University, North Grafton, MA, USA., Potter BM; Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA., Prescott JO; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Saunders AB; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Sawyer HM; Olympic Veterinary Cardiology, Everett, WA, USA., Scansen BA; Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA., Schmid SM; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Smith CC; Chesapeake Veterinary Cardiology Associates, Lawndale, CA, USA., Tjostheim SS; Department of Medical Sciences, University of Wisconsin, Madison, WI, USA., Tolbert MK; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Tropf MA; Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA., Visser LC; Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA., Ward JL; Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA., Wesselowski SR; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA., Windsor RC; Wheat Ridge Animal Hospital, Wheat Ridge, CO, USA., Yang VK; Department of Clinical Sciences, Tufts University, North Grafton, MA, USA., Ruple A; Department of Population and Health Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA., Promislow DEL; Jean Mayer USDA Human Nutrition Research Center On Aging, Tufts University, Boston, MA, USA., Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.; Optispan, Inc, Seattle, WA, USA.
Corporate Authors: Dog Aging Project Consortium
Source: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 2851-2877. Date of Electronic Publication: 2025 Feb 14.
Publication Type: Clinical Trial Protocol; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.
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