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Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization.

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Title: Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization.
Authors: Pelucchi S; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Da Dalt L; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., De Cesare G; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Stringhi R; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., D'Andrea L; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., La Greca F; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Cambria C; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milan, Italy., Vandermeulen L; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Zianni E; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Musardo S; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Roda S; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Bonacina F; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Nasini S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Lupo MG; Department of Medicine, University of Padua, Padua, Italy., Ferri N; Department of Medicine, University of Padua, Padua, Italy; VIMM, Veneto Institute of Molecular Medicine, Padua, Italy., Comai S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy; Department of Biomedical Sciences, University of Padua, Padua, Italy; Department of Psychiatry, McGill University, Montreal, QC, Canada; IRCSS San Raffaele Scientific Institute, Milan, Italy., Gardoni F; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Antonucci F; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milan, Italy; Institute of Neuroscience, IN-CNR, Milano, Italy., Scheggia D; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Di Luca M; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Norata GD; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy. Electronic address: danilo.norata@unimi.it., Marcello E; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy. Electronic address: elena.marcello@unimi.it.
Source: Pharmacological research [Pharmacol Res] 2025 Mar; Vol. 213, pp. 107652. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
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  Data: Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization.
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  Data: <searchLink fieldCode="AU" term="%22Pelucchi+S%22">Pelucchi S</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Da+Dalt+L%22">Da Dalt L</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Cesare+G%22">De Cesare G</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Stringhi+R%22">Stringhi R</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22D'Andrea+L%22">D'Andrea L</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22La+Greca+F%22">La Greca F</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cambria+C%22">Cambria C</searchLink>; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vandermeulen+L%22">Vandermeulen L</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zianni+E%22">Zianni E</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Musardo+S%22">Musardo S</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Roda+S%22">Roda S</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonacina+F%22">Bonacina F</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Nasini+S%22">Nasini S</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Lupo+MG%22">Lupo MG</searchLink>; Department of Medicine, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Ferri+N%22">Ferri N</searchLink>; Department of Medicine, University of Padua, Padua, Italy; VIMM, Veneto Institute of Molecular Medicine, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Comai+S%22">Comai S</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy; Department of Biomedical Sciences, University of Padua, Padua, Italy; Department of Psychiatry, McGill University, Montreal, QC, Canada; IRCSS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gardoni+F%22">Gardoni F</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Antonucci+F%22">Antonucci F</searchLink>; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milan, Italy; Institute of Neuroscience, IN-CNR, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Scheggia+D%22">Scheggia D</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Luca+M%22">Di Luca M</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Norata+GD%22">Norata GD</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy. Electronic address: danilo.norata@unimi.it.<br /><searchLink fieldCode="AU" term="%22Marcello+E%22">Marcello E</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy. Electronic address: elena.marcello@unimi.it.
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