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A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cells.

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Title: A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cells.
Authors: Severino MB; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Morelli AP; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Pavan ICB; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Mancini MCS; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Góis MM; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Borges RJ; Department of Physics and Biophysics, Biosciences Institute, State University of São Paulo, Botucatu, Brazil; Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas, Campinas, Brazil; Center for Medicinal Chemistry (CQMED), University of Campinas, Campinas, Brazil., Braga RR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, Brazil., da Silva LGS; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Quintero-Ruiz N; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Costa MM; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Oliveira WL; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Bezerra RMN; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil., Ropelle ER; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, Brazil., Simabuco FM; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil; Applied Molecular Signaling Laboratory (LabSIMA), Department of Biochemistry, Federal University of São Paulo, São Paulo, Brazil. Electronic address: simabuco@gmail.com.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Mar; Vol. 301 (3), pp. 108308. Date of Electronic Publication: 2025 Feb 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Severino+MB%22">Severino MB</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Morelli+AP%22">Morelli AP</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Pavan+ICB%22">Pavan ICB</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Mancini+MCS%22">Mancini MCS</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Góis+MM%22">Góis MM</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Borges+RJ%22">Borges RJ</searchLink>; Department of Physics and Biophysics, Biosciences Institute, State University of São Paulo, Botucatu, Brazil; Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas, Campinas, Brazil; Center for Medicinal Chemistry (CQMED), University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Braga+RR%22">Braga RR</searchLink>; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+LGS%22">da Silva LGS</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Quintero-Ruiz+N%22">Quintero-Ruiz N</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+MM%22">Costa MM</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliveira+WL%22">Oliveira WL</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Bezerra+RMN%22">Bezerra RMN</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Ropelle+ER%22">Ropelle ER</searchLink>; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Simabuco+FM%22">Simabuco FM</searchLink>; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, University of Campinas, Limeira, Brazil; Applied Molecular Signaling Laboratory (LabSIMA), Department of Biochemistry, Federal University of São Paulo, São Paulo, Brazil. Electronic address: simabuco@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Mar; Vol. 301 (3), pp. 108308. <i>Date of Electronic Publication: </i>2025 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2025.108308
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              Text: 2025 Mar
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