Phase 2b, open-label, single-arm, multicenter pilot study of the efficacy, safety, and tolerability of dostarlimab in women with early-stage mismatch repair-deficient endometrioid endometrial adenocarcinoma.

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Title: Phase 2b, open-label, single-arm, multicenter pilot study of the efficacy, safety, and tolerability of dostarlimab in women with early-stage mismatch repair-deficient endometrioid endometrial adenocarcinoma.
Authors: Obermair A; Royal Brisbane and Women's Hospital Campus, UQ Centre for Clinical Research, The University of Queensland, Queensland Centre for Gynaecological Cancer (QCGC) Research, Herston, QLD, Australia. Electronic address: a.obermair@uq.edu.au., Gebski V; The University of Sydney, Faculty of Medicine and Health, NHMRC Clinical Trials Centre, Camperdown, NSW, Australia., Goh J; Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., Kuchel A; Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, QLD, Australia; University of Queensland, The School of Medicine, Herston, QLD, Australia., Brand A; Westmead Hospital, The Crown Princess Mary Cancer Centre, Westmead, NSW, Australia; Westmead Centre for Gynaecological Oncology, The University of Sydney, Camperdown, NSW, Australia., Mak B; The University of Sydney, Faculty of Medicine and Health, NHMRC Clinical Trials Centre, Camperdown, NSW, Australia; Westmead Hospital, The Crown Princess Mary Cancer Centre, Westmead, NSW, Australia., McNally O; Oncology and Dysplasia Service, The Royal Women's Hospital, Parkville, VIC, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, VIC, Australia; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Baxter E; Royal Brisbane and Women's Hospital Campus, UQ Centre for Clinical Research, The University of Queensland, Queensland Centre for Gynaecological Cancer (QCGC) Research, Herston, QLD, Australia., Jobling T; Monash University, Department of Obstetrics and Gynaecology, Clayton, VIC, Australia; Monash Health, Women's and Newborn Program, Clayton, VIC, Australia., Mileshkin L; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Source: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2025 Apr; Vol. 35 (4), pp. 101644. Date of Electronic Publication: 2025 Jan 16.
Publication Type: Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BMJ Country of Publication: United States NLM ID: 9111626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1438 (Electronic) Linking ISSN: 1048891X NLM ISO Abbreviation: Int J Gynecol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-1438
DOI:10.1016/j.ijgc.2025.101644