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Isolation and structure elucidation of Dm-CVNH, a new cyanovirin-N homolog with activity against SARS-CoV-2 and HIV-1.

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Title: Isolation and structure elucidation of Dm-CVNH, a new cyanovirin-N homolog with activity against SARS-CoV-2 and HIV-1.
Authors: Orfanoudaki M; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Krumpe LRH; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Shenoy SR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Wilson J; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Guszczynski T; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Henrich CJ; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Temme JS; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Gildersleeve JC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., Molina-Molina E; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain., Erkizia I; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain., Blanco J; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain; Department of Infectious Diseases and Immunity, Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain; CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Izquierdo-Useros N; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain; CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Montiero F; Embrapa Genetic Resources and Biotechnology National Institute of Science and Technology in Synthetic Biology, Brasília, Brazil., Tanuri A; Embrapa Genetic Resources and Biotechnology National Institute of Science and Technology in Synthetic Biology, Brasília, Brazil., Rech E; Embrapa Genetic Resources and Biotechnology National Institute of Science and Technology in Synthetic Biology, Brasília, Brazil., O'Keefe BR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA; Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA. Electronic address: okeefeba@mail.nih.gov.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Mar; Vol. 301 (3), pp. 108319. Date of Electronic Publication: 2025 Feb 14.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Isolation and structure elucidation of Dm-CVNH, a new cyanovirin-N homolog with activity against SARS-CoV-2 and HIV-1.
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  Data: <searchLink fieldCode="AU" term="%22Orfanoudaki+M%22">Orfanoudaki M</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Krumpe+LRH%22">Krumpe LRH</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Shenoy+SR%22">Shenoy SR</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+J%22">Wilson J</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Guszczynski+T%22">Guszczynski T</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Henrich+CJ%22">Henrich CJ</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Temme+JS%22">Temme JS</searchLink>; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gildersleeve+JC%22">Gildersleeve JC</searchLink>; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Molina-Molina+E%22">Molina-Molina E</searchLink>; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Erkizia+I%22">Erkizia I</searchLink>; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco+J%22">Blanco J</searchLink>; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain; Department of Infectious Diseases and Immunity, Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain; CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Izquierdo-Useros+N%22">Izquierdo-Useros N</searchLink>; IrsiCaixa, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain; CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Montiero+F%22">Montiero F</searchLink>; Embrapa Genetic Resources and Biotechnology National Institute of Science and Technology in Synthetic Biology, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22Tanuri+A%22">Tanuri A</searchLink>; Embrapa Genetic Resources and Biotechnology National Institute of Science and Technology in Synthetic Biology, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22Rech+E%22">Rech E</searchLink>; Embrapa Genetic Resources and Biotechnology National Institute of Science and Technology in Synthetic Biology, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22O'Keefe+BR%22">O'Keefe BR</searchLink>; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA; Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA. Electronic address: okeefeba@mail.nih.gov.
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