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Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape.

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Title: Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape.
Authors: Cook AL; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, United States., Sur S; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States., Dobbyn L; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States., Watson E; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States., Cohen JD; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States., Ptak B; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States., Lee BS; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States., Paul S; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States., Hsiue E; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States., Popoli M; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States., Vogelstein B; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.; Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, United States., Papadopoulos N; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States., Bettegowda C; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, United States., Gabrielson K; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, United States., Zhou S; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States., Kinzler KW; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.; Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, United States., Wyhs N; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.
Source: ELife [Elife] 2025 Feb 17; Vol. 13. Date of Electronic Publication: 2025 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cook+AL%22">Cook AL</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, United States.<br /><searchLink fieldCode="AU" term="%22Sur+S%22">Sur S</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.; Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.<br /><searchLink fieldCode="AU" term="%22Dobbyn+L%22">Dobbyn L</searchLink>; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, United States.<br /><searchLink fieldCode="AU" term="%22Watson+E%22">Watson E</searchLink>; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, United States.<br /><searchLink fieldCode="AU" term="%22Cohen+JD%22">Cohen JD</searchLink>; 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