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Discovery of the novel celastrol-based PROTACs for the treatment of non-small cell lung cancer.

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Title: Discovery of the novel celastrol-based PROTACs for the treatment of non-small cell lung cancer.
Authors: Ma C; Department of Clinical Laboratory, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China., Wang F; School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong Province, China.; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China., Wang Y; School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong Province, China., Wu F; School of Medical Laboratory, Shandong Second Medical University, Weifang, 261053, Shandong Province, China., Zhang X; Department of Clinical Laboratory, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China., Ding C; Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China., Zhao J; Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China., Ma Y; School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China., Li W; School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong Province, China. liwz@sdsmu.edu.cn., Liu W; Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China. liuwenshan@sdsmu.edu.cn.; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China. liuwenshan@sdsmu.edu.cn.
Source: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6121-6135. Date of Electronic Publication: 2025 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of the novel celastrol-based PROTACs for the treatment of non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Department of Clinical Laboratory, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong Province, China.; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; School of Medical Laboratory, Shandong Second Medical University, Weifang, 261053, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Clinical Laboratory, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Ding+C%22">Ding C</searchLink>; Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong Province, China. liwz@sdsmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China. liuwenshan@sdsmu.edu.cn.; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, 261041, Shandong Province, China. liuwenshan@sdsmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229516534%22">Molecular diversity</searchLink> [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6121-6135. <i>Date of Electronic Publication: </i>2025 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ESCOM+Science+Publishers%22">ESCOM Science Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9516534 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-501X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213811991%22">13811991 </searchLink><i>NLM ISO Abbreviation: </i>Mol Divers <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11030-025-11140-7
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            – D: 01
              M: 12
              Text: 2025 Dec
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