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Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab.

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Title: Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab.
Authors: Myojin Y; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Babaei S; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Trehan R; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Hoffman C; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Kedei N; Collaborative Protein Technology Resources, Office of Science and Technology Resources, National Institutes of Health, Bethesda, Maryland, USA., Ruf B; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Benmebarek MR; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Bauer KC; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Huang P; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Ma C; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Monge C; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Xie C; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Hrones D; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Duffy AG; Mater Misericordiae University Hospital, Dublin, Ireland., Armstrong P; Mater Misericordiae University Hospital, Dublin, Ireland., Kocheise L; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Desmond F; Mater Misericordiae University Hospital, Dublin, Ireland., Buchalter J; Mater Misericordiae University Hospital, Dublin, Ireland., Galligan M; Clinical Research Centre, University College Dublin, Dublin, Ireland., Cantwell C; St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Ryan R; St Vincent's University Hospital, University College Dublin, Dublin, Ireland., McCann J; St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Bourke M; St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Mac Nicholas R; St Vincent's University Hospital, University College Dublin, Dublin, Ireland., McDermott R; St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Awosika J; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Cam M; Center for Collaborative Bioinformatics, National Institutes of Health, Bethesda, Maryland, USA., Krebs R; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Budhu A; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Revsine M; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Figg WD; Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Kleiner DE; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Redd B; Radiology and Imaging Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Wood BJ; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Radiology and Imaging Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Center for Interventional Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Wang XW; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Korangy F; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Claassen M; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Greten TF; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA tim.greten@nih.gov.; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Source: Gut [Gut] 2025 May 07; Vol. 74 (6), pp. 983-995. Date of Electronic Publication: 2025 May 07.
Publication Type: Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
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  Data: Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab.
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  Data: <searchLink fieldCode="AU" term="%22Myojin+Y%22">Myojin Y</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Babaei+S%22">Babaei S</searchLink>; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Trehan+R%22">Trehan R</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+C%22">Hoffman C</searchLink>; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kedei+N%22">Kedei N</searchLink>; Collaborative Protein Technology Resources, Office of Science and Technology Resources, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ruf+B%22">Ruf B</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; 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Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Xie+C%22">Xie C</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hrones+D%22">Hrones D</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Duffy+AG%22">Duffy AG</searchLink>; Mater Misericordiae University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Armstrong+P%22">Armstrong P</searchLink>; Mater Misericordiae University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Kocheise+L%22">Kocheise L</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Desmond+F%22">Desmond F</searchLink>; Mater Misericordiae University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Buchalter+J%22">Buchalter J</searchLink>; Mater Misericordiae University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Galligan+M%22">Galligan M</searchLink>; Clinical Research Centre, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Cantwell+C%22">Cantwell C</searchLink>; St Vincent's University Hospital, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Ryan+R%22">Ryan R</searchLink>; St Vincent's University Hospital, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22McCann+J%22">McCann J</searchLink>; St Vincent's University Hospital, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Bourke+M%22">Bourke M</searchLink>; St Vincent's University Hospital, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Mac+Nicholas+R%22">Mac Nicholas R</searchLink>; St Vincent's University Hospital, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22McDermott+R%22">McDermott R</searchLink>; St Vincent's University Hospital, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Awosika+J%22">Awosika J</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cam+M%22">Cam M</searchLink>; Center for Collaborative Bioinformatics, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Krebs+R%22">Krebs R</searchLink>; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Budhu+A%22">Budhu A</searchLink>; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Revsine+M%22">Revsine M</searchLink>; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Figg+WD%22">Figg WD</searchLink>; Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kleiner+DE%22">Kleiner DE</searchLink>; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Redd+B%22">Redd B</searchLink>; Radiology and Imaging Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wood+BJ%22">Wood BJ</searchLink>; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Radiology and Imaging Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Center for Interventional Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wang+XW%22">Wang XW</searchLink>; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Korangy+F%22">Korangy F</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Claassen+M%22">Claassen M</searchLink>; Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tubingen, Germany.; Department of Internal Medicine I (Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases and Geriatrics), University Hospital Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Greten+TF%22">Greten TF</searchLink>; Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA tim.greten@nih.gov.; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
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