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Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity.

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Title: Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity.
Authors: Chapsal BD; Pfizer-Boulder, Boulder, Colorado 80301, United States., Kimbrough JR; Pfizer-Boulder, Boulder, Colorado 80301, United States., Bester SM; Pfizer-Boulder, Boulder, Colorado 80301, United States., Bergstrom A; Pfizer-Boulder, Boulder, Colorado 80301, United States., Backos DS; Pfizer-Boulder, Boulder, Colorado 80301, United States., Campos B; Pfizer-Boulder, Boulder, Colorado 80301, United States., McDonald MG; Pfizer-Boulder, Boulder, Colorado 80301, United States., Abrahamsen R; Pfizer-Boulder, Boulder, Colorado 80301, United States., Allen AC; Pfizer-Boulder, Boulder, Colorado 80301, United States., Doerner Barbour PM; Pfizer-Boulder, Boulder, Colorado 80301, United States., Bettendorf T; Pfizer-Boulder, Boulder, Colorado 80301, United States., Boys ML; Pfizer-Boulder, Boulder, Colorado 80301, United States., Brown K; Pfizer-Boulder, Boulder, Colorado 80301, United States., Chicarelli MJ; Pfizer-Boulder, Boulder, Colorado 80301, United States., Cook AW; Pfizer-Boulder, Boulder, Colorado 80301, United States., Crooks AL; Pfizer-Boulder, Boulder, Colorado 80301, United States., Cruz CL; Pfizer-Boulder, Boulder, Colorado 80301, United States., Dahlke JR; Pfizer-Boulder, Boulder, Colorado 80301, United States., Eide A; Pfizer-Boulder, Boulder, Colorado 80301, United States., Fell JB; Pfizer-Boulder, Boulder, Colorado 80301, United States., Fulton JL; Pfizer-Boulder, Boulder, Colorado 80301, United States., Gargus M; Pfizer-Boulder, Boulder, Colorado 80301, United States., Gaudino JJ; Pfizer-Boulder, Boulder, Colorado 80301, United States., Guarnieri AL; Pfizer-Boulder, Boulder, Colorado 80301, United States., Hansen EP; Pfizer-Boulder, Boulder, Colorado 80301, United States., Holt MC; Pfizer-Boulder, Boulder, Colorado 80301, United States., Kahn DR; Pfizer-Boulder, Boulder, Colorado 80301, United States., Laird ER; Pfizer-Boulder, Boulder, Colorado 80301, United States., Larsen PD; Pfizer-Boulder, Boulder, Colorado 80301, United States., Linwood R; Pfizer-Boulder, Boulder, Colorado 80301, United States., Martinson MC; Pfizer-Boulder, Boulder, Colorado 80301, United States., McCown J; Pfizer-Boulder, Boulder, Colorado 80301, United States., Mejia MJ; Pfizer-Boulder, Boulder, Colorado 80301, United States., Moreno DA; Pfizer-Boulder, Boulder, Colorado 80301, United States., Mou TC; Pfizer-Boulder, Boulder, Colorado 80301, United States., Newhouse B; Pfizer-Boulder, Boulder, Colorado 80301, United States., O'Leary JM; Pfizer-Boulder, Boulder, Colorado 80301, United States., Rodriguez ME; Pfizer-Boulder, Boulder, Colorado 80301, United States., Singh A; Pfizer-Boulder, Boulder, Colorado 80301, United States., Sinik L; Pfizer-Boulder, Boulder, Colorado 80301, United States., Strand KA; Pfizer-Boulder, Boulder, Colorado 80301, United States., Touney EE; Pfizer-Boulder, Boulder, Colorado 80301, United States., Wollenberg LA; Pfizer-Boulder, Boulder, Colorado 80301, United States., Wong J; Pfizer-Boulder, Boulder, Colorado 80301, United States., Zhou Y; Pfizer-Boulder, Boulder, Colorado 80301, United States., Fischer JP; Pfizer-Boulder, Boulder, Colorado 80301, United States., Allen S; Pfizer-Boulder, Boulder, Colorado 80301, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Dec 31; Vol. 16 (2), pp. 224-233. Date of Electronic Publication: 2024 Dec 31 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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