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Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.

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Title: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.
Authors: Al Bakir M; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Reading JL; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Pre-Cancer Immunology Laboratory, Research Department of Haematology, University College London Cancer Institute, London, UK., Gamble S; Pre-Cancer Immunology Laboratory, Research Department of Haematology, University College London Cancer Institute, London, UK., Rosenthal R; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Uddin I; Division of Infection and Immunity, University College London, London, UK., Rowan A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Przewrocka J; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Rogers A; Pre-Cancer Immunology Laboratory, Research Department of Haematology, University College London Cancer Institute, London, UK., Wong YNS; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Bentzen AK; Pre-Cancer Immunology Laboratory, Research Department of Haematology, University College London Cancer Institute, London, UK., Veeriah S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Ward S; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Genomics Science Technology Platform, The Francis Crick Institute, London, UK., Garnett AT; Invitae Inc., Boulder, CO, USA., Kalavakur P; Invitae Inc., Boulder, CO, USA., Martínez-Ruiz C; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Puttick C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Huebner A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Cook DE; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Moore DA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospital NHS Foundation Trust, London, UK., Abbosh C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Hiley CT; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Naceur-Lombardelli C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Watkins TBK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Petkovic M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Biology, Humboldt University of Berlin, Berlin, Germany.; Division of Oncology and Hematology, Department of Pediatrics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany., Schwarz RF; Institute for Computational Cancer Biology (ICCB), Center for Integrated Oncology (CIO), Cancer Research Center Cologne Essen (CCCE), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Berlin Institute for the Foundations of Learning and Data (BIFOLD), Berlin, Germany., Gálvez-Cancino F; Immune-Regulation and Immune-Interactions Laboratory, Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Headington, UK., Litchfield K; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Meldgaard P; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Sorensen BS; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark., Madsen LB; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Jäger D; Department of Medical Oncology, National Center for Tumor Diseases Heidelberg, Heidelberg University Hospital, Heidelberg, Germany., Forster MD; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Oncology, UCL Cancer Institute, London, UK., Arkenau T; Sarah Cannon Research Institute, London, UK., Domingo-Vila C; Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK., Tree TIM; Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK., Kadivar M; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Hadrup SR; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Chain B; Division of Infection and Immunity, University College London, London, UK.; Department of Computer Sciences, University College London, London, UK., Quezada SA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. s.quezada@ucl.ac.uk.; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. s.quezada@ucl.ac.uk., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK. nicholas.mcgranahan.10@ucl.ac.uk., Swanton C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.
Source: Nature [Nature] 2025 Mar; Vol. 639 (8056), pp. 1052-1059. Date of Electronic Publication: 2025 Feb 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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