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Human-correlated genetic models identify precision therapy for liver cancer.

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Title: Human-correlated genetic models identify precision therapy for liver cancer.
Authors: Müller M; Cancer Research UK Scotland Institute, Glasgow, UK. miryam_mueller@yahoo.com., May S; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Hall H; Cancer Research UK Scotland Institute, Glasgow, UK., Kendall TJ; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., McGarry L; Cancer Research UK Scotland Institute, Glasgow, UK., Blukacz L; Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland., Nuciforo S; Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland., Georgakopoulou A; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Jamieson T; Cancer Research UK Scotland Institute, Glasgow, UK., Phinichkusolchit N; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Dhayade S; Cancer Research UK Scotland Institute, Glasgow, UK., Suzuki T; Cancer Research UK Scotland Institute, Glasgow, UK., Huguet-Pradell J; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain., Powley IR; Cancer Research UK Scotland Institute, Glasgow, UK., Officer-Jones L; Cancer Research UK Scotland Institute, Glasgow, UK., Pennie RL; Cancer Research UK Scotland Institute, Glasgow, UK., Esteban-Fabró R; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain., Gris-Oliver A; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain., Pinyol R; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain., Skalka GL; Cancer Research UK Scotland Institute, Glasgow, UK., Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Hoare M; Early Cancer Institute, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Sprangers J; Cancer Research UK Scotland Institute, Glasgow, UK., Malviya G; Cancer Research UK Scotland Institute, Glasgow, UK., Mackintosh A; Cancer Research UK Scotland Institute, Glasgow, UK., Johnson E; Cancer Research UK Scotland Institute, Glasgow, UK., McCain M; The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK., Halpin J; Cancer Research UK Scotland Institute, Glasgow, UK., Kiourtis C; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Nixon C; Cancer Research UK Scotland Institute, Glasgow, UK., Clark G; Cancer Research UK Scotland Institute, Glasgow, UK., Clark W; Cancer Research UK Scotland Institute, Glasgow, UK., Shaw R; Cancer Research UK Scotland Institute, Glasgow, UK., Hedley A; Cancer Research UK Scotland Institute, Glasgow, UK., Drake TM; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK., Tan EH; Cancer Research UK Scotland Institute, Glasgow, UK., Neilson M; Cancer Research UK Scotland Institute, Glasgow, UK., Murphy DJ; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Lewis DY; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Reeves HL; The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Liver Group, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Le Quesne J; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Department of Histopathology, Queen Elizabeth University Hospital, Glasgow, UK., Mann DA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; The Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey., Carlin LM; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Blyth K; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Llovet JM; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain., Heim MH; Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland.; University Digestive Health Care Center Basel-Clarunis, Basel, Switzerland., Sansom OJ; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Scotland Centre, Edinburgh, UK.; Cancer Research UK Scotland Centre, Glasgow, UK., Miller CJ; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Bird TG; Cancer Research UK Scotland Institute, Glasgow, UK. t.bird@crukscotlandinstitute.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. t.bird@crukscotlandinstitute.ac.uk.; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. t.bird@crukscotlandinstitute.ac.uk.; Cancer Research UK Scotland Centre, Edinburgh, UK. t.bird@crukscotlandinstitute.ac.uk.; Cancer Research UK Scotland Centre, Glasgow, UK. t.bird@crukscotlandinstitute.ac.uk.
Source: Nature [Nature] 2025 Mar; Vol. 639 (8055), pp. 754-764. Date of Electronic Publication: 2025 Feb 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
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