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A phase III randomized study of first-line NUC-1031/cisplatin vs. gemcitabine/cisplatin in advanced biliary tract cancer.

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Title: A phase III randomized study of first-line NUC-1031/cisplatin vs. gemcitabine/cisplatin in advanced biliary tract cancer.
Authors: Knox JJ; Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address: Jennifer.knox@uhn.ca., McNamara MG; University of Manchester/The Christie NHS Foundation Trust, Manchester, UK., Bazin IS; N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russia., Oh DY; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, South Korea., Zubkov O; The State Institute 'Shalimov`s National Institute of Surgery and Transplantology' NAMS of Ukraine, Kyiv, Ukraine., Breder V; N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russia., Bai LY; Division of Hematology and Oncology, China Medical University Hospital, and China Medical University, Taichung, Taiwan., Christie A; Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK., Goyal L; Massachusetts General Hospital, Boston, USA; Stanford University School of Medicine, Palo Alto, California, USA., Cosgrove DP; Division of Medical Oncology, Vancouver Cancer Center, Compass Oncology, Vancouver, USA., Springfeld C; Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases, Heidelberg, Germany., Sjoquist KM; Cancer Care Centre, St George Hospital, Kogarah & NHMRC Clinical Trials Centre, University of Sydney, Australia., Park JO; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Verdaguer H; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain., Braconi C; University of Glasgow & Beatson West of Scotland Cancer Centre, Glasgow, UK., Ross PJ; Guy's Cancer, Guy's & St Thomas' NHS Foundation Trust, London, UK., De Gramont A; Franco-British Institute, Levallois-Perret, France., Shroff RT; Division of Hematology/Oncology, Department of Medicine, University of Arizona Cancer Center, Tucson, USA., Zalcberg JR; Dept Medical Oncology, Alfred Health and School of Public Health Monash University, Melbourne Australia., Palmer DH; University of Liverpool and The Clatterbridge Cancer Centre, Liverpool, UK., Smith JR; Adaptive Plus LLC, North Carolina, USA., Oelmann E; NuCana plc, Edinburgh, UK., Bruce T; NuCana plc, Edinburgh, UK., Valle JW; University of Manchester/The Christie NHS Foundation Trust, Manchester, UK; Cholangiocarcinoma Foundation, Utah, USA.
Source: Journal of hepatology [J Hepatol] 2025 Aug; Vol. 83 (2), pp. 358-366. Date of Electronic Publication: 2025 Feb 18.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase III randomized study of first-line NUC-1031/cisplatin vs. gemcitabine/cisplatin in advanced biliary tract cancer.
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  Data: <searchLink fieldCode="AU" term="%22Knox+JJ%22">Knox JJ</searchLink>; Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address: Jennifer.knox@uhn.ca.<br /><searchLink fieldCode="AU" term="%22McNamara+MG%22">McNamara MG</searchLink>; University of Manchester/The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Bazin+IS%22">Bazin IS</searchLink>; N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Oh+DY%22">Oh DY</searchLink>; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Zubkov+O%22">Zubkov O</searchLink>; The State Institute 'Shalimov`s National Institute of Surgery and Transplantology' NAMS of Ukraine, Kyiv, Ukraine.<br /><searchLink fieldCode="AU" term="%22Breder+V%22">Breder V</searchLink>; N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Bai+LY%22">Bai LY</searchLink>; Division of Hematology and Oncology, China Medical University Hospital, and China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Christie+A%22">Christie A</searchLink>; Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Goyal+L%22">Goyal L</searchLink>; Massachusetts General Hospital, Boston, USA; Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Cosgrove+DP%22">Cosgrove DP</searchLink>; Division of Medical Oncology, Vancouver Cancer Center, Compass Oncology, Vancouver, USA.<br /><searchLink fieldCode="AU" term="%22Springfeld+C%22">Springfeld C</searchLink>; Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sjoquist+KM%22">Sjoquist KM</searchLink>; Cancer Care Centre, St George Hospital, Kogarah & NHMRC Clinical Trials Centre, University of Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Park+JO%22">Park JO</searchLink>; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Verdaguer+H%22">Verdaguer H</searchLink>; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Braconi+C%22">Braconi C</searchLink>; University of Glasgow & Beatson West of Scotland Cancer Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ross+PJ%22">Ross PJ</searchLink>; Guy's Cancer, Guy's & St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22De+Gramont+A%22">De Gramont A</searchLink>; Franco-British Institute, Levallois-Perret, France.<br /><searchLink fieldCode="AU" term="%22Shroff+RT%22">Shroff RT</searchLink>; Division of Hematology/Oncology, Department of Medicine, University of Arizona Cancer Center, Tucson, USA.<br /><searchLink fieldCode="AU" term="%22Zalcberg+JR%22">Zalcberg JR</searchLink>; Dept Medical Oncology, Alfred Health and School of Public Health Monash University, Melbourne Australia.<br /><searchLink fieldCode="AU" term="%22Palmer+DH%22">Palmer DH</searchLink>; University of Liverpool and The Clatterbridge Cancer Centre, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Smith+JR%22">Smith JR</searchLink>; Adaptive Plus LLC, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Oelmann+E%22">Oelmann E</searchLink>; NuCana plc, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Bruce+T%22">Bruce T</searchLink>; NuCana plc, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Valle+JW%22">Valle JW</searchLink>; University of Manchester/The Christie NHS Foundation Trust, Manchester, UK; Cholangiocarcinoma Foundation, Utah, USA.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2025 Aug; Vol. 83 (2), pp. 358-366. <i>Date of Electronic Publication: </i>2025 Feb 18.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comparative Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jhep.2025.01.040
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