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Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response.

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Title: Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response.
Authors: Leung C; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada., Park HY; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Li X; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada., Koelwyn GJ; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada., Tuong J; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada., Vahedi SM; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada., Leitao Filho FS; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Division of Pulmonary Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil., Yang JS; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada., Eddy RL; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Department of Radiology, University of British Columbia, Vancouver, BC, Canada., Milne S; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Ryu MH; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Takiguchi H; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan., Akata K; Division of Infection Control and Prevention, University of Occupational and Environmental Health, Kitakyushu City, Japan., Ra SW; Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea., Moon JY; Division of Pulmonary and Allergy, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea., Kim HK; Department of Internal Medicine, College of Medicine, Inje University Haeundae Paik Hospital, Busan, South Korea., Cho Y; Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea., Yamasaki K; Department of Respiratory Medicine, University of Occupational and Environmental Health Japan, Fukuoka, Japan., van Eeden SF; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada., Shaipanich T; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada., Lam S; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; British Columbia Cancer Agency, Vancouver, BC, Canada., Leung JM; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada., Sin DD; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada don.sin@hli.ubc.ca.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Source: The European respiratory journal [Eur Respir J] 2025 May 06; Vol. 65 (5). Date of Electronic Publication: 2025 May 06 (Print Publication: 2025).
Publication Type: Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response.
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  Data: <searchLink fieldCode="AU" term="%22Leung+C%22">Leung C</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Park+HY%22">Park HY</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Koelwyn+GJ%22">Koelwyn GJ</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Tuong+J%22">Tuong J</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Vahedi+SM%22">Vahedi SM</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Leitao+Filho+FS%22">Leitao Filho FS</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Division of Pulmonary Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Yang+JS%22">Yang JS</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Eddy+RL%22">Eddy RL</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Department of Radiology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Milne+S%22">Milne S</searchLink>; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Faculty of Medicine and Health, University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Ryu+MH%22">Ryu MH</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Takiguchi+H%22">Takiguchi H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan.<br /><searchLink fieldCode="AU" term="%22Akata+K%22">Akata K</searchLink>; Division of Infection Control and Prevention, University of Occupational and Environmental Health, Kitakyushu City, Japan.<br /><searchLink fieldCode="AU" term="%22Ra+SW%22">Ra SW</searchLink>; Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Moon+JY%22">Moon JY</searchLink>; Division of Pulmonary and Allergy, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HK%22">Kim HK</searchLink>; Department of Internal Medicine, College of Medicine, Inje University Haeundae Paik Hospital, Busan, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+Y%22">Cho Y</searchLink>; Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea.<br /><searchLink fieldCode="AU" term="%22Yamasaki+K%22">Yamasaki K</searchLink>; Department of Respiratory Medicine, University of Occupational and Environmental Health Japan, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22van+Eeden+SF%22">van Eeden SF</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Shaipanich+T%22">Shaipanich T</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lam+S%22">Lam S</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; British Columbia Cancer Agency, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Leung+JM%22">Leung JM</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Sin+DD%22">Sin DD</searchLink>; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada don.sin@hli.ubc.ca.; Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
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  Data: <searchLink fieldCode="JN" term="%228803460%22">The European respiratory journal</searchLink> [Eur Respir J] 2025 May 06; Vol. 65 (5). <i>Date of Electronic Publication: </i>2025 May 06 (<i>Print Publication: </i>2025).
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  Data: Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22European+Respiratory+Society%22">European Respiratory Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8803460 <i>Publication Model: </i>Electronic-Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1399-3003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209031936%22">09031936 </searchLink><i>NLM ISO Abbreviation: </i>Eur Respir J <i>Subsets: </i>MEDLINE
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