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Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant.

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Title: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant.
Authors: Lim SY; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Toh TS; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Hor JW; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lim JL; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lit LC; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Ahmad-Annuar A; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Tay YW; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Laboratory of Neurogenetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore., Ng EY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Muthusamy KA; Division of Neurosurgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Mohamed Ibrahim N; Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Ibrahim KA; Department of Medicine, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Terengganu, Malaysia., Tan LCS; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Zulkefli J; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; Immunogenetic Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health Complex, Ministry of Health Malaysia, Setia Alam, Malaysia., Khairul Anuar AN; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Black K; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK., Lis P; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK., Xie F; Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China., Cen Z; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China., Lim KS; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lohmann K; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany., Padmanabhan S; The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA., Alessi DR; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK., Luo W; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China., Tan EK; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Sammler E; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK. e.m.sammler@dundee.ac.uk.; Division of Neuroscience, School of Medicine, University of Dundee, Dundee, UK. e.m.sammler@dundee.ac.uk., Tan AH; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. aihuey.tan@gmail.com.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. aihuey.tan@gmail.com.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Feb 23; Vol. 11 (1), pp. 34. Date of Electronic Publication: 2025 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant.
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  Data: <searchLink fieldCode="AU" term="%22Lim+SY%22">Lim SY</searchLink>; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Toh+TS%22">Toh TS</searchLink>; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Hor+JW%22">Hor JW</searchLink>; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Lim+JL%22">Lim JL</searchLink>; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Lit+LC%22">Lit LC</searchLink>; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ahmad-Annuar+A%22">Ahmad-Annuar A</searchLink>; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Tay+YW%22">Tay YW</searchLink>; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Foo+JN%22">Foo JN</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Laboratory of Neurogenetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+EY%22">Ng EY</searchLink>; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Muthusamy+KA%22">Muthusamy KA</searchLink>; Division of Neurosurgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Mohamed+Ibrahim+N%22">Mohamed Ibrahim N</searchLink>; Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ibrahim+KA%22">Ibrahim KA</searchLink>; Department of Medicine, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Terengganu, Malaysia.<br /><searchLink fieldCode="AU" term="%22Tan+LCS%22">Tan LCS</searchLink>; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zulkefli+J%22">Zulkefli J</searchLink>; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; Immunogenetic Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health Complex, Ministry of Health Malaysia, Setia Alam, Malaysia.<br /><searchLink fieldCode="AU" term="%22Khairul+Anuar+AN%22">Khairul Anuar AN</searchLink>; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Black+K%22">Black K</searchLink>; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Lis+P%22">Lis P</searchLink>; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Xie+F%22">Xie F</searchLink>; Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.<br /><searchLink fieldCode="AU" term="%22Cen+Z%22">Cen Z</searchLink>; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.<br /><searchLink fieldCode="AU" term="%22Lim+KS%22">Lim KS</searchLink>; Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Lohmann+K%22">Lohmann K</searchLink>; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Padmanabhan+S%22">Padmanabhan S</searchLink>; The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alessi+DR%22">Alessi DR</searchLink>; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Luo+W%22">Luo W</searchLink>; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.<br /><searchLink fieldCode="AU" term="%22Tan+EK%22">Tan EK</searchLink>; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sammler+E%22">Sammler E</searchLink>; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK. e.m.sammler@dundee.ac.uk.; Division of Neuroscience, School of Medicine, University of Dundee, Dundee, UK. e.m.sammler@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tan+AH%22">Tan AH</searchLink>; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. aihuey.tan@gmail.com.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. aihuey.tan@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2025 Feb 23; Vol. 11 (1), pp. 34. <i>Date of Electronic Publication: </i>2025 Feb 23.
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