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Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

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Title: Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.
Authors: von Delft F; Diamond Light Source., Ni X; University of Oxford., Richardson R; University of Texas Southwestern Medical Center., Godoy A; University of Sao Paulo., Ferla M; University of Oxford., Kikawa C; University of Washington., Scheen J; Open Molecular Software Foundation., Hannon W; Fred Hutch Cancer Center., Capkin E; Diamond Light Source., Lahav N; The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science., Balcomb B; Diamond Light Source., Marples P; Diamond Light Source Ltd., Fairhead M; Centre for Medicines Discovery, University of Oxford., Wang S; University of Oxford., Williams E; University of Oxford., Tomlinson C; Diamond Light Source., Aschenbrenner J; Diamond Light Source Ltd., Lithgo R; Diamond Light Source., Winokan M; Diamond Light Source Ltd., Giroud C; University of Oxford., Chandran A; Diamond Light Source., Walsh M; Diamond Light Source., Thompson W; Diamond Light Source, UK., Bloom J; Fred Hutchinson Cancer Center., Barr H; Weizmann Institute of Science., Kirkegaard K; Stanford University., Koekemoer L; Oxford University., Fearon D; Diamond Light Source., Evans M; Icahn School of Medicine at Mount Sinai.
Source: Research square [Res Sq] 2025 Feb 13. Date of Electronic Publication: 2025 Feb 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22von+Delft+F%22">von Delft F</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Ni+X%22">Ni X</searchLink>; University of Oxford.<br /><searchLink fieldCode="AU" term="%22Richardson+R%22">Richardson R</searchLink>; University of Texas Southwestern Medical Center.<br /><searchLink fieldCode="AU" term="%22Godoy+A%22">Godoy A</searchLink>; University of Sao Paulo.<br /><searchLink fieldCode="AU" term="%22Ferla+M%22">Ferla M</searchLink>; University of Oxford.<br /><searchLink fieldCode="AU" term="%22Kikawa+C%22">Kikawa C</searchLink>; University of Washington.<br /><searchLink fieldCode="AU" term="%22Scheen+J%22">Scheen J</searchLink>; Open Molecular Software Foundation.<br /><searchLink fieldCode="AU" term="%22Hannon+W%22">Hannon W</searchLink>; Fred Hutch Cancer Center.<br /><searchLink fieldCode="AU" term="%22Capkin+E%22">Capkin E</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Lahav+N%22">Lahav N</searchLink>; The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science.<br /><searchLink fieldCode="AU" term="%22Balcomb+B%22">Balcomb B</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Marples+P%22">Marples P</searchLink>; Diamond Light Source Ltd.<br /><searchLink fieldCode="AU" term="%22Fairhead+M%22">Fairhead M</searchLink>; Centre for Medicines Discovery, University of Oxford.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; University of Oxford.<br /><searchLink fieldCode="AU" term="%22Williams+E%22">Williams E</searchLink>; University of Oxford.<br /><searchLink fieldCode="AU" term="%22Tomlinson+C%22">Tomlinson C</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Aschenbrenner+J%22">Aschenbrenner J</searchLink>; Diamond Light Source Ltd.<br /><searchLink fieldCode="AU" term="%22Lithgo+R%22">Lithgo R</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Winokan+M%22">Winokan M</searchLink>; Diamond Light Source Ltd.<br /><searchLink fieldCode="AU" term="%22Giroud+C%22">Giroud C</searchLink>; University of Oxford.<br /><searchLink fieldCode="AU" term="%22Chandran+A%22">Chandran A</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Walsh+M%22">Walsh M</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Thompson+W%22">Thompson W</searchLink>; Diamond Light Source, UK.<br /><searchLink fieldCode="AU" term="%22Bloom+J%22">Bloom J</searchLink>; Fred Hutchinson Cancer Center.<br /><searchLink fieldCode="AU" term="%22Barr+H%22">Barr H</searchLink>; Weizmann Institute of Science.<br /><searchLink fieldCode="AU" term="%22Kirkegaard+K%22">Kirkegaard K</searchLink>; Stanford University.<br /><searchLink fieldCode="AU" term="%22Koekemoer+L%22">Koekemoer L</searchLink>; Oxford University.<br /><searchLink fieldCode="AU" term="%22Fearon+D%22">Fearon D</searchLink>; Diamond Light Source.<br /><searchLink fieldCode="AU" term="%22Evans+M%22">Evans M</searchLink>; Icahn School of Medicine at Mount Sinai.
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              Text: 2025 Feb 13
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