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Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum.

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Title: Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum.
Authors: Bay S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rodina A; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Haut F; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA., Roychowdhury T; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Argyrousi EK; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA., Staniszewski A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA., Han K; Tanz Centre for Research in Neurodegenerative Diseases and Department of Medical Biophysics, University of Toronto, Toronto, ON M5R 0A3, Canada., Sharma S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chakrabarty S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Digwal CS; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Stanisavljevic A; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA., Labuza A; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA., Alldred MJ; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA.; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA., Panchal P; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., SanthaSeela A; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Tuffery L; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Li Z; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hashmi A; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rosiek E; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chan E; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Monetti M; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Sasaguri H; Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan., Saido TC; Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612., Fraser PE; Tanz Centre for Research in Neurodegenerative Diseases and Department of Medical Biophysics, University of Toronto, Toronto, ON M5R 0A3, Canada., Erdjument-Bromage H; Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY, 10016, USA., Neubert TA; Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY, 10016, USA.; NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA., Ginsberg SD; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA.; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA.; NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA., Arancio O; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA.; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA., Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Source: Research square [Res Sq] 2025 Feb 12. Date of Electronic Publication: 2025 Feb 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Tanz Centre for Research in Neurodegenerative Diseases and Department of Medical Biophysics, University of Toronto, Toronto, ON M5R 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+S%22">Chakrabarty S</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Digwal+CS%22">Digwal CS</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Stanisavljevic+A%22">Stanisavljevic A</searchLink>; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA.<br /><searchLink fieldCode="AU" term="%22Labuza+A%22">Labuza A</searchLink>; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA.<br /><searchLink fieldCode="AU" term="%22Alldred+MJ%22">Alldred MJ</searchLink>; 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Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chan+E%22">Chan E</searchLink>; Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Monetti+M%22">Monetti M</searchLink>; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Sasaguri+H%22">Sasaguri H</searchLink>; Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.<br /><searchLink fieldCode="AU" term="%22Saido+TC%22">Saido TC</searchLink>; Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612.<br /><searchLink fieldCode="AU" term="%22Fraser+PE%22">Fraser PE</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases and Department of Medical Biophysics, University of Toronto, Toronto, ON M5R 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Erdjument-Bromage+H%22">Erdjument-Bromage H</searchLink>; Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY, 10016, USA.<br /><searchLink fieldCode="AU" term="%22Neubert+TA%22">Neubert TA</searchLink>; Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY, 10016, USA.; NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Ginsberg+SD%22">Ginsberg SD</searchLink>; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, 10962, USA.; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA.; NYU Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Arancio+O%22">Arancio O</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA.; Department of Medicine, Columbia University, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Chiosis+G%22">Chiosis G</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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